Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 8/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 4/20 | 0.36 |
| ▸ | PGR | P06401 | 2/20 | 0.35 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.35 |
| ▸ | AR | P10275 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4484186 | 0.85 | NR3C1 (0.42) | NR3C1KMT2AGAAKDM4EPGR | |
| SCHEMBL4484871 | 0.83 | KDM4E (0.44) | NR3C1KMT2AKDM4EPGRNR3C2 | |
| SCHEMBL4486735 | 0.83 | NR3C1 (0.40) | NR3C1PGRNR3C2ARBCHE | |
| SCHEMBL6665773 | 0.81 | NR3C1 (0.37) | NR3C1PGRNR3C2AR | |
| SCHEMBL1120828 | 0.76 | NR3C1 (0.41) | NR3C1PGRNR3C2AR | |
| SCHEMBL1120796 | 0.76 | NR3C1 (0.43) | NR3C1PGRNR3C2AR | |
| Hydrochloric Acid SCHEMBL1120842 | 0.75 | NR3C1 (0.43) | NR3C1PGRNR3C2AR | |
| SCHEMBL1120856 | 0.75 | NR3C1 (0.40) | NR3C1KMT2AMAPTPGRNR3C2 | |
| SCHEMBL1120902 | 0.74 | NR3C1 (0.42) | NR3C1GAAMAPTKDM4EPGR | |
| SCHEMBL1120929 | 0.74 | KDM4E (0.45) | NR3C1SMN1; SMN2KMT2AGAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1935882-A1 | Bicyclic compounds | Asahi Kasei Pharma Corporation (JP) | 2008-06-25 | — | — | EP | disclosed |
| EP-1447400-A1 | BICYCLIC COMPOUND | Asahi Kasei Pharma Corporation (JP) | 2004-08-18 | — | — | EP | disclosed |