Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 8/20 | 0.41 |
| ▸ | ALPL | P05186 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | WRN | Q14191 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4322585 | 0.95 | CYP2C19 (0.39) | GRM5ALPLCYP2C19ALDH1A1SMN1; SMN2 | |
| SCHEMBL4322600 | 0.91 | GRM5 (0.48) | GRM5 | |
| SCHEMBL4339114 | 0.85 | ALDH1A1 (0.48) | GRM5CYP2C19ALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL4330704 | 0.82 | GRM5 (0.53) | GRM5 | |
| SCHEMBL4335376 | 0.81 | GRM5 (0.59) | GRM5ALDH1A1NPSR1 | |
| SCHEMBL4331727 | 0.79 | CYP2C19 (0.40) | GRM5ALPLCYP2C19ALDH1A1SMN1; SMN2 | |
| SCHEMBL4321156 | 0.77 | CYP2C19 (0.39) | GRM5ALPLCYP2C19ALDH1A1HPGD | |
| SCHEMBL5313596 | 0.77 | CYP11B1 (0.39) | GRM5CYP2C19ALDH1A1HPGDHTT | |
| SCHEMBL13706915 | 0.77 | CYP2C19 (0.42) | GRM5ALPLCYP2C19ALDH1A1SMN1; SMN2 | |
| SCHEMBL4335429 | 0.74 | GRM5 (0.50) | GRM5ALDH1A1HPGDNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1931635-A1 | TETRAHYDROQUINOLINONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Merz Pharma GmbH & Co.KGaA (DE) | 2008-06-18 | — | — | EP | disclosed |
| WO-2007023290-A1 | TETRAHYDROQUINOLINONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2007-03-01 | — | — | WO | disclosed |