Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 4/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 6/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4322600 | 0.85 | GRM5 (0.48) | CYP11B1CYP11B2NPY5RGRM5CYP1A2 | |
| SCHEMBL4636436 | 0.81 | ALDH1A1 (0.41) | CYP11B1CYP11B2TSHRKDM4EHSD17B10 | |
| SCHEMBL4635243 | 0.77 | GRM5 (0.41) | HTTGRM5ALDH1A1HPGDCYP2C19 | |
| SCHEMBL4330704 | 0.77 | GRM5 (0.53) | CYP11B1CYP11B2GRM5 | |
| SCHEMBL4322585 | 0.75 | CYP2C19 (0.39) | KDM4EHTTGRM5ALDH1A1HPGD | |
| SCHEMBL4335376 | 0.72 | GRM5 (0.59) | TSHRKDM4EGRM5ALDH1A1 | |
| SCHEMBL28024470 | 0.68 | CYP11B1 (0.55) | CYP11B1CYP11B2NPY5RTSHRKDM4E | |
| SCHEMBL4335429 | 0.65 | GRM5 (0.50) | CYP11B1CYP11B2KDM4EHSD17B10GRM5 | |
| SCHEMBL4328401 | 0.64 | GRM5 (0.63) | GRM5 | |
| SCHEMBL4330065 | 0.64 | GRM5 (0.48) | CYP11B1CYP11B2NPY5RGRM5CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007023242-A1 | TETRAHYDROQUINOLINONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2007-03-01 | — | — | WO | claimed |