Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 14/20 | 0.48 |
| ▸ | HTR2B | P41595 | 4/20 | 0.47 |
| ▸ | DRD2 | P14416 | 3/20 | 0.47 |
| ▸ | HTR2C | P28335 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | HTR1D | P28221 | 1/20 | 0.34 |
| ▸ | HTR1B | P28222 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3532161 | 0.96 | HTR6 (0.51) | HTR6HTR2BDRD2HTR2CTP53 | |
| SCHEMBL3531703 | 0.91 | HTR6 (0.57) | HTR6HTR2BDRD2HTR2CCA12 | |
| SCHEMBL3534239 | 0.82 | HTR6 (0.52) | HTR6HTR2BDRD2HTR2CTP53 | |
| SCHEMBL3532651 | 0.81 | HTR6 (0.53) | HTR6HTR2BDRD2HTR2CTP53 | |
| SCHEMBL3531338 | 0.81 | HTR6 (0.53) | HTR6HTR2BDRD2HTR2CTP53 | |
| SCHEMBL3532673 | 0.81 | HTR6 (0.53) | HTR6HTR2BDRD2HTR2CTP53 | |
| SCHEMBL3532315 | 0.81 | HTR6 (0.53) | HTR6HTR2BDRD2HTR2CCA12 | |
| SCHEMBL3532495 | 0.81 | HTR6 (0.52) | HTR6HTR2BDRD2HTR2CTP53 | |
| SCHEMBL3534496 | 0.80 | HTR6 (0.52) | HTR6HTR2BDRD2HTR2CTP53 | |
| SCHEMBL3532494 | 0.80 | HTR6 (0.52) | HTR6HTR2BDRD2HTR2CTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1931640-A2 | SUBSTITUTED-3-SULFONYLINDAZOLE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | Wyeth a Corporation of the State of Delaware (US) | 2008-06-18 | — | — | EP | disclosed |
| WO-2007021711-A2 | SUBSTITUTED-3-SULFONYLINDAZOLE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | WYETH (US) | 2007-02-22 | — | — | WO | disclosed |