Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 13/20 | 0.71 |
| ▸ | HTR2A | P28223 | 12/20 | 0.71 |
| ▸ | HTR2C | P28335 | 4/20 | 0.71 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.71 |
| ▸ | ACHE | P22303 | 3/20 | 0.71 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.71 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.71 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.71 |
| ▸ | DRD1 | P21728 | 2/20 | 0.71 |
| ▸ | DRD4 | P21917 | 2/20 | 0.71 |
| ▸ | DRD5 | P21918 | 2/20 | 0.71 |
| ▸ | HTR1D | P28221 | 2/20 | 0.71 |
| ▸ | HTR1B | P28222 | 2/20 | 0.71 |
| ▸ | HTR7 | P34969 | 2/20 | 0.71 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.71 |
| ▸ | HRH1 | P35367 | 2/20 | 0.71 |
| ▸ | DRD3 | P35462 | 2/20 | 0.71 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.71 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.71 |
| ▸ | HTR1A | P08908 | 2/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3146202 | 0.89 | DRD2 (0.77) | DRD2HTR2AHTR2CKCNH2ACHE | |
| SCHEMBL4616132 | 0.86 | DRD2 (0.53) | DRD2HTR2AHTR2CKCNH2ACHE | |
| SCHEMBL7283232 | 0.85 | DRD2 (0.72) | DRD2HTR2AHTR2CKCNH2ACHE | |
| SCHEMBL9594506 | 0.84 | DRD2 (0.74) | DRD2HTR2AHTR2CKCNH2ACHE | |
| SCHEMBL7952591 | 0.84 | DRD2 (0.74) | DRD2HTR2AHTR2CKCNH2ACHE | |
| SCHEMBL16263410 | 0.84 | DRD2 (0.73) | DRD2HTR2AHTR2CKCNH2ACHE | |
| SCHEMBL7323722 | 0.83 | DRD2 (0.75) | DRD2HTR2AHTR2CKCNH2ACHE | |
| Risperidone SCHEMBL27911 | 0.83 | DRD2 (1.00) | DRD2HTR2AHTR2CKCNH2ACHE | |
| Risperidone SCHEMBL5070793 | 0.83 | DRD2 (1.00) | DRD2HTR2AHTR2CKCNH2ACHE | |
| SCHEMBL9594562 | 0.83 | DRD2 (0.77) | DRD2HTR2AHTR2CKCNH2ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080214808-A1 | Preparation of Aseptic 3-[2-[4-((6-Fluoro-1,2-Benzisoxazol-3-Yl)-1-Piperidinyl]-6,7,8,9-Tetrahydro-9-Hydroxy-2-Methyl-4H-Pyrido[1,2-a]Pyrimidin-4-One Palmitate Ester | SPITTAELS THOMAS FREDERIK ERNESTINE | 2008-09-04 | — | — | US | claimed |
| EP-1879890-A1 | PREPARATION OF ASEPTIC 3-[2-[4-(6-FLUORO-1,2-BENZISOXAZOL-3-YL)-1-PIPERIDINYL]ETHYL]-6,7,8,9-TETRAHYDRO-9-HYDROXY-2-METHYL-4H-PYRIDIO[1,2-A]PYRIMIDIN-4-ONE PALMITATE ESTER | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-01-23 | — | — | EP | claimed |
| WO-2006114384-A1 | PREPARATION OF ASEPTIC 3-[2-[4-(6-FLUORO-1,2-BENZISOXAZOL-3-YL)-1-PIPERIDINYL]ETHYL]-6,7,8,9-TETRAHYDRO-9-HYDROXY-2-METHYL-4H-PYRIDIO[1,2-A]PYRIMIDIN-4-ONE PALMITATE ESTER | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-11-02 | — | — | WO | claimed |
| CN-101163702-B | Preparation of sterile 3- [2- [4- (6-fluoro-1) | JANSSEN PHARMACEUTICA NV | 2011-09-07 | — | — | CN | disclosed |
| US-20080214808-A1 | Preparation of Aseptic 3-[2-[4-((6-Fluoro-1,2-Benzisoxazol-3-Yl)-1-Piperidinyl]-6,7,8,9-Tetrahydro-9-Hydroxy-2-Methyl-4H-Pyrido[1,2-a]Pyrimidin-4-One Palmitate Ester | SPITTAELS THOMAS FREDERIK ERNESTINE | 2008-09-04 | — | — | US | disclosed |
| US-20080214808-A1 | Preparation of Aseptic 3-[2-[4-((6-Fluoro-1,2-Benzisoxazol-3-Yl)-1-Piperidinyl]-6,7,8,9-Tetrahydro-9-Hydroxy-2-Methyl-4H-Pyrido[1,2-a]Pyrimidin-4-One Palmitate Ester | SPITTAELS THOMAS FREDERIK ERNESTINE | 2008-09-04 | — | — | US | disclosed |
| US-20080214808-A1 | Preparation of Aseptic 3-[2-[4-((6-Fluoro-1,2-Benzisoxazol-3-Yl)-1-Piperidinyl]-6,7,8,9-Tetrahydro-9-Hydroxy-2-Methyl-4H-Pyrido[1,2-a]Pyrimidin-4-One Palmitate Ester | SPITTAELS THOMAS FREDERIK ERNESTINE | 2008-09-04 | — | — | US | disclosed |
| US-20080214808-A1 | Preparation of Aseptic 3-[2-[4-((6-Fluoro-1,2-Benzisoxazol-3-Yl)-1-Piperidinyl]-6,7,8,9-Tetrahydro-9-Hydroxy-2-Methyl-4H-Pyrido[1,2-a]Pyrimidin-4-One Palmitate Ester | SPITTAELS THOMAS FREDERIK ERNESTINE | 2008-09-04 | — | — | US | disclosed |
| CN-101163702-A | Preparation of sterile 3- [ 2- [ 4- (6-fluoro-1, 2-benziso * oxazol-3-yl) -1-piperidinyl ] ethyl ] -6, 7,8, 9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido [1, 2-a ] pyrimidin-4-one palmitate | JANSSEN PHARMACEUTICA NV (BE) | 2008-04-16 | — | — | CN | disclosed |
| EP-1879890-A1 | PREPARATION OF ASEPTIC 3-[2-[4-(6-FLUORO-1,2-BENZISOXAZOL-3-YL)-1-PIPERIDINYL]ETHYL]-6,7,8,9-TETRAHYDRO-9-HYDROXY-2-METHYL-4H-PYRIDIO[1,2-A]PYRIMIDIN-4-ONE PALMITATE ESTER | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-01-23 | — | — | EP | disclosed |
| EP-1879890-A1 | PREPARATION OF ASEPTIC 3-[2-[4-(6-FLUORO-1,2-BENZISOXAZOL-3-YL)-1-PIPERIDINYL]ETHYL]-6,7,8,9-TETRAHYDRO-9-HYDROXY-2-METHYL-4H-PYRIDIO[1,2-A]PYRIMIDIN-4-ONE PALMITATE ESTER | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-01-23 | — | — | EP | disclosed |
| WO-2006114384-A1 | PREPARATION OF ASEPTIC 3-[2-[4-(6-FLUORO-1,2-BENZISOXAZOL-3-YL)-1-PIPERIDINYL]ETHYL]-6,7,8,9-TETRAHYDRO-9-HYDROXY-2-METHYL-4H-PYRIDIO[1,2-A]PYRIMIDIN-4-ONE PALMITATE ESTER | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-11-02 | — | — | WO | disclosed |
| WO-2006114384-A1 | PREPARATION OF ASEPTIC 3-[2-[4-(6-FLUORO-1,2-BENZISOXAZOL-3-YL)-1-PIPERIDINYL]ETHYL]-6,7,8,9-TETRAHYDRO-9-HYDROXY-2-METHYL-4H-PYRIDIO[1,2-A]PYRIMIDIN-4-ONE PALMITATE ESTER | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-11-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080214808-A1 | Preparation of Aseptic 3-[2-[4-((6-Fluoro-1,2-Benzisoxazol-3-Yl)-1-Piperidinyl]-6,7,8,9-Tetrahydro-9-Hydroxy-2-Methyl-4H-Pyrido[1,2-a]Pyrimidin-4-One Palmitate Ester | CASP1, FFAR1, FFAR4 | DRD2 3643/4885HTR2A 1860/4885HTR2C 2619/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.