⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1269153 | 0.97 | KDM4E (0.32) | — | |
| SCHEMBL8718542 | 0.94 | — | — | |
| Hydrochloric Acid SCHEMBL23174550 | 0.91 | — | — | |
| SCHEMBL3985738 | 0.87 | — | — | |
| SCHEMBL4720625 | 0.84 | — | — | |
| SCHEMBL4231793 | 0.82 | HRH3 (0.32) | — | |
| SCHEMBL4765150 | 0.80 | L3MBTL1 (0.32) | — | |
| SCHEMBL16099104 | 0.80 | — | — | |
| SCHEMBL4721344 | 0.78 | L3MBTL1 (0.34) | — | |
| SCHEMBL7851389 | 0.77 | SMN1; SMN2 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 40 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109575045-A | Thienopyrimidines, preparation method, Pharmaceutical composition and its application | 南京红云生物科技有限公司 | 2019-04-05 | — | — | CN | claimed |
| WO-2008057420-A2 | EXTENDED TRITERPENE DERIVATIVES | PANACOS PHARMACEUTICALS, INC. (US) | 2008-05-15 | — | — | WO | claimed |
| EP-1307429-B1 | PROCESS FOR ASYMMETRIC SYNTHESIS OF SUBSTITUTED 1,4-DIHYDROPYRIDINES | ASTRAZENECA AB (SE) | 2007-11-28 | — | — | EP | claimed |
| US-7074931-B2 | Process for asymmetric synthesis of substituted 1,4 -dihydropyridines | ASTRAZENECA AB (SE) | 2006-07-11 | — | — | US | claimed |
| US-20040039207-A1 | Process for asymmetric synthesis of substituted 1,4 -dihydropyridines | ASTRAZENECA AB (SE) | 2004-02-26 | — | — | US | claimed |
| EP-1307429-A1 | PROCESS FOR ASYMMETRIC SYNTHESIS OF SUBSTITUTED 1,4-DIHYDROPYRIDINES | AstraZeneca AB (SE) | 2003-05-07 | — | — | EP | claimed |
| WO-2002010134-A1 | PROCESS FOR ASYMMETRIC SYNTHESIS OF SUBSTITUTED 1,4-DIHYDROPYRIDINES | ASTRAZENECA AB (SE) | 2002-02-07 | — | — | WO | claimed |
| US-10980816-B2 | Thienopyrimidine derivatives, processes for the preparation thereof and therapeutic uses thereof | SANOFI (FR) | 2021-04-20 | — | — | US | disclosed |
| US-20200323874-A1 | NOVEL THIENOPYRIMIDINE DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF AND THERAPEUTIC USES THEREOF | SANOFI (FR) | 2020-10-15 | — | — | US | disclosed |
| US-10736904-B2 | Thienopyrimidine derivatives, processes for the preparation thereof and therapeutic uses thereof | SANOFI (FR) | 2020-08-11 | — | — | US | disclosed |
| US-20200078370-A1 | NOVEL THIENOPYRIMIDINE DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF AND THERAPEUTIC USES THEREOF | SANOFI (FR) | 2020-03-12 | — | — | US | disclosed |
| US-20190151330-A1 | NOVEL THIENOPYRIMIDINE DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF AND THERAPEUTIC USES THEREOF | SANOFI (FR) | 2019-05-23 | — | — | US | disclosed |
| CN-109575045-A | Thienopyrimidines, preparation method, Pharmaceutical composition and its application | 南京红云生物科技有限公司 | 2019-04-05 | — | — | CN | disclosed |
| US-7074931-B2 | Process for asymmetric synthesis of substituted 1,4 -dihydropyridines | ASTRAZENECA AB (SE) | 2006-07-11 | — | — | US | disclosed |
| US-20040039207-A1 | Process for asymmetric synthesis of substituted 1,4 -dihydropyridines | ASTRAZENECA AB (SE) | 2004-02-26 | — | — | US | disclosed |
| EP-1307429-A1 | PROCESS FOR ASYMMETRIC SYNTHESIS OF SUBSTITUTED 1,4-DIHYDROPYRIDINES | AstraZeneca AB (SE) | 2003-05-07 | — | — | EP | disclosed |
| WO-2002010134-A1 | PROCESS FOR ASYMMETRIC SYNTHESIS OF SUBSTITUTED 1,4-DIHYDROPYRIDINES | ASTRAZENECA AB (SE) | 2002-02-07 | — | — | WO | disclosed |
| EP-1152011-A1 | PEPTIDES INHIBITING VASCULAR ENDOTHELIAL CELL MIGRATION | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2001-11-07 | — | — | EP | disclosed |
| WO-1995015955-A1 | 2,4-DIAMINOTHIAZOLES AND THEIR PRODUCTION | BASF AKTIENGESELLSCHAFT (DE) | 1995-06-15 | — | — | WO | disclosed |
| US-5391819-A | Process of making chiral 2-aryl-1,4-butanediamine derivatives as useful neurokinin-A antagonists | MERCK & CO., INC. (US) | 1995-02-21 | — | — | US | disclosed |