Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 9/20 | 0.41 |
| ▸ | SLC6A4 known ✓ | P31645 | 8/20 | 0.41 |
| ▸ | KCNH2 known ✓ | Q12809 | 4/20 | 0.41 |
| ▸ | HRH1 known ✓ | P35367 | 2/20 | 0.36 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.35 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | BCL9 | O00512 | 2/20 | 0.34 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL4635673 | 1.00 | SLC6A2 (0.41) | SLC6A2SLC6A4SLC6A3KCNH2HRH1 | |
| Fumaric Acid SCHEMBL4635667 | 1.00 | SLC6A2 (0.41) | SLC6A2SLC6A4SLC6A3KCNH2HRH1 | |
| Fumaric Acid SCHEMBL4139366 | 0.93 | SLC6A2 (0.41) | SLC6A2SLC6A4SLC6A3KCNH2HRH1 | |
| Fumaric Acid SCHEMBL4139373 | 0.93 | SLC6A2 (0.41) | SLC6A2SLC6A4SLC6A3KCNH2HRH1 | |
| Fumaric Acid SCHEMBL4139372 | 0.93 | SLC6A2 (0.41) | SLC6A2SLC6A4SLC6A3KCNH2HRH1 | |
| Fumaric Acid SCHEMBL4669519 | 0.91 | SLC6A2 (0.40) | SLC6A2SLC6A4SLC6A3KCNH2HRH1 | |
| Fumaric Acid SCHEMBL4635676 | 0.88 | SLC6A2 (0.39) | SLC6A2SLC6A4SLC6A3KCNH2HRH1 | |
| Fumaric Acid SCHEMBL4635680 | 0.88 | SLC6A2 (0.39) | SLC6A2SLC6A4SLC6A3KCNH2HRH1 | |
| Fumaric Acid SCHEMBL4635666 | 0.88 | SLC6A2 (0.39) | SLC6A2SLC6A4SLC6A3KCNH2HRH1 | |
| SCHEMBL13741260 | 0.84 | SLC6A2 (0.47) | SLC6A2SLC6A4SLC6A3KCNH2F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1931653-A2 | THERAPEUTIC PYRROLIDINES | Pfizer Products Inc. (US) | 2008-06-18 | — | — | EP | disclosed |
| WO-2007031828-A2 | THERAPEUTIC PYRROLIDINES | PFIZER PRODUCTS INC. (US) | 2007-03-22 | — | — | WO | disclosed |