Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 9/20 | 0.41 |
| ▸ | SLC6A4 known ✓ | P31645 | 8/20 | 0.41 |
| ▸ | KCNH2 known ✓ | Q12809 | 4/20 | 0.41 |
| ▸ | CHRM3 known ✓ | P20309 | 4/20 | 0.36 |
| ▸ | HRH1 known ✓ | P35367 | 3/20 | 0.36 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A known ✓ | Q03164 | 1/20 | 0.35 |
| ▸ | CHRM2 known ✓ | P08172 | 2/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | BCL9 | O00512 | 2/20 | 0.35 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL4139373 | 1.00 | SLC6A2 (0.41) | SLC6A2SLC6A4SLC6A3KCNH2CHRM3 | |
| Fumaric Acid SCHEMBL4139372 | 1.00 | SLC6A2 (0.41) | SLC6A2SLC6A4SLC6A3KCNH2CHRM3 | |
| Fumaric Acid SCHEMBL4635667 | 0.93 | SLC6A2 (0.41) | SLC6A2SLC6A4SLC6A3KCNH2CHRM3 | |
| Fumaric Acid SCHEMBL4635673 | 0.93 | SLC6A2 (0.41) | SLC6A2SLC6A4SLC6A3KCNH2CHRM3 | |
| Fumaric Acid SCHEMBL4635663 | 0.93 | SLC6A2 (0.41) | SLC6A2SLC6A4SLC6A3KCNH2CHRM3 | |
| SCHEMBL13741260 | 0.92 | SLC6A2 (0.47) | SLC6A2SLC6A4SLC6A3KCNH2CHRM3 | |
| Fumaric Acid SCHEMBL4669519 | 0.91 | SLC6A2 (0.40) | SLC6A2SLC6A4SLC6A3KCNH2HRH1 | |
| Fumaric Acid SCHEMBL4635676 | 0.88 | SLC6A2 (0.39) | SLC6A2SLC6A4SLC6A3KCNH2HRH1 | |
| Fumaric Acid SCHEMBL4635666 | 0.88 | SLC6A2 (0.39) | SLC6A2SLC6A4SLC6A3KCNH2HRH1 | |
| Fumaric Acid SCHEMBL4635680 | 0.88 | SLC6A2 (0.39) | SLC6A2SLC6A4SLC6A3KCNH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090215857-A1 | Therapeutic Pyrrolidines | PFIZER PRODUCTS INC. (US) | 2009-08-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215857-A1 | Therapeutic Pyrrolidines | OPRL1, HTR5A, OPRD1 | SLC6A2 28/4885SLC6A4 18/4885KCNH2 673/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.