Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.53 |
| ▸ | NPC1 | O15118 | 5/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | DAO | P14920 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.45 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | DRD5 | P21918 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29405082 | 0.85 | NPC1 (0.59) | RAB9ANPC1SMN1; SMN2KDM4EDAO | |
| SCHEMBL432670 | 0.85 | NPC1 (0.59) | RAB9ANPC1SMN1; SMN2KDM4EDAO | |
| SCHEMBL15702601 | 0.83 | ALDH1A1 (0.66) | RAB9ANPC1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL8362996 | 0.82 | NPC1 (0.56) | RAB9ANPC1SMN1; SMN2KDM4EDAO | |
| SCHEMBL9656225 | 0.82 | DAO (0.55) | RAB9ANPC1SMN1; SMN2KDM4EDAO | |
| SCHEMBL11163593 | 0.82 | NPC1 (0.58) | RAB9ANPC1SMN1; SMN2KDM4EDAO | |
| SCHEMBL1457922 | 0.82 | NPC1 (0.53) | RAB9ANPC1SMN1; SMN2KDM4EDAO | |
| SCHEMBL3388873 | 0.82 | L3MBTL1 (0.54) | RAB9ANPC1SMN1; SMN2KDM4EDAO | |
| SCHEMBL11231567 | 0.81 | MAPT (0.55) | RAB9ANPC1SMN1; SMN2KDM4EDAO | |
| Hydrochloric Acid SCHEMBL11174365 | 0.81 | NPC1 (0.57) | RAB9ANPC1SMN1; SMN2KDM4EDAO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4394509-A | CHEMICAL INTERMEDIATES FOR SULFOXIDE DERIVATIVES USEFUL AS ANTIULCER AND ANTISECRETORY AGENTS | JOHN WYETH AND BROTHER LIMITED (GB) | 1983-07-19 | — | — | US | claimed |
| US-20080306109-A1 | Indolizine Derivatives as Ligands of the Crth2 Receptor | ARGENTA DISCOVERY LIMITED (GB) | 2008-12-11 | — | — | US | disclosed |
| CN-101305001-A | Indolizine derivatives as ligands of the CRTH2 receptor | ARGENTA DISCOVERY LTD (GB) | 2008-11-12 | — | — | CN | disclosed |
| EP-1931663-A1 | IMDOLIZINE DERIVATIVES AS LIGANDS OF THE CRTH2 RECEPTOR | Argenta Discovery Limited (GB) | 2008-06-18 | — | — | EP | disclosed |
| WO-2007031747-A1 | IMDOLIZINE DERIVATIVES AS LIGANDS OF THE CRTH2 RECEPTOR | ARGENTA DISCOVERY LIMITED (GB) | 2007-03-22 | — | — | WO | disclosed |
| US-4394509-A | CHEMICAL INTERMEDIATES FOR SULFOXIDE DERIVATIVES USEFUL AS ANTIULCER AND ANTISECRETORY AGENTS | JOHN WYETH AND BROTHER LIMITED (GB) | 1983-07-19 | — | — | US | disclosed |
| US-4327102-A | TREATING ULCERS AND HYPERSECRETION | JOHN WYETH & BROTHER LIMITED (GB) | 1982-04-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080306109-A1 | Indolizine Derivatives as Ligands of the Crth2 Receptor | HRH4, HRH2, HRH3 | RAB9A 2059/4885NPC1 934/4885SMN1; SMN2 4618/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.