Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | SNCA | P37840 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.39 |
| ▸ | GPR183 | P32249 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4635932 | 1.00 | MAPT (0.44) | MAPTALDH1A1MAPK1L3MBTL1AKR1C3 | |
| SCHEMBL3530886 | 0.88 | ALDH1A1 (0.46) | MAPTALDH1A1MAPK1L3MBTL1POLB | |
| SCHEMBL3531827 | 0.85 | ALDH1A1 (0.42) | MAPTALDH1A1MAPK1HTTPOLB | |
| SCHEMBL3530892 | 0.84 | ALDH1A1 (0.42) | MAPTALDH1A1MAPK1L3MBTL1AKR1C3 | |
| SCHEMBL3530887 | 0.84 | ALDH1A1 (0.42) | MAPTALDH1A1MAPK1L3MBTL1AKR1C3 | |
| SCHEMBL3530890 | 0.84 | ALDH1A1 (0.42) | MAPTALDH1A1MAPK1L3MBTL1AKR1C3 | |
| SCHEMBL4636830 | 0.84 | POLB (0.53) | MAPTALDH1A1MAPK1L3MBTL1HTT | |
| SCHEMBL4636829 | 0.84 | POLB (0.53) | MAPTALDH1A1MAPK1L3MBTL1HTT | |
| SCHEMBL3534757 | 0.78 | ALDH1A1 (0.43) | MAPTALDH1A1MAPK1HTTPOLB | |
| SCHEMBL1814309 | 0.78 | ALDH1A1 (0.43) | MAPTALDH1A1MAPK1HTTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1931640-A2 | SUBSTITUTED-3-SULFONYLINDAZOLE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | Wyeth a Corporation of the State of Delaware (US) | 2008-06-18 | — | — | EP | disclosed |
| WO-2007021711-A2 | SUBSTITUTED-3-SULFONYLINDAZOLE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | WYETH (US) | 2007-02-22 | — | — | WO | disclosed |