Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 6/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | SNCA | P37840 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | DBH | P09172 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4636830 | 1.00 | POLB (0.53) | POLBHTTALDH1A1KMT2AATM | |
| SCHEMBL3532565 | 0.88 | ALDH1A1 (0.49) | POLBHTTALDH1A1KMT2AATM | |
| SCHEMBL4635932 | 0.84 | MAPT (0.44) | POLBHTTALDH1A1KMT2AATM | |
| SCHEMBL4635927 | 0.84 | MAPT (0.44) | POLBHTTALDH1A1KMT2AATM | |
| SCHEMBL3532566 | 0.81 | ALDH1A1 (0.54) | POLBHTTALDH1A1KMT2AATM | |
| SCHEMBL3532567 | 0.81 | ALDH1A1 (0.54) | POLBHTTALDH1A1KMT2AATM | |
| SCHEMBL5594752 | 0.79 | PLA2G4A (0.50) | POLBALDH1A1KMT2AMEN1GAA | |
| SCHEMBL5594757 | 0.79 | PLA2G4A (0.50) | POLBALDH1A1KMT2AMEN1GAA | |
| SCHEMBL5594749 | 0.79 | PLA2G4A (0.50) | POLBALDH1A1KMT2AMEN1GAA | |
| SCHEMBL3535128 | 0.76 | HTT (0.60) | POLBHTTALDH1A1KMT2AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1931640-A2 | SUBSTITUTED-3-SULFONYLINDAZOLE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | Wyeth a Corporation of the State of Delaware (US) | 2008-06-18 | — | — | EP | disclosed |
| WO-2007021711-A2 | SUBSTITUTED-3-SULFONYLINDAZOLE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | WYETH (US) | 2007-02-22 | — | — | WO | disclosed |