Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | CLPP | Q16740 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | PDE2A | O00408 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4233101 | 0.84 | HSD11B1 (0.50) | HSD11B1MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL4598435 | 0.84 | ALDH1A1 (0.56) | HSD11B1MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL4233173 | 0.83 | MEN1 (0.47) | HSD11B1MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL4232158 | 0.82 | HSD11B1 (0.69) | HSD11B1MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL4227442 | 0.82 | ALDH1A1 (0.54) | HSD11B1MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL4236491 | 0.81 | HSD11B1 (0.60) | HSD11B1MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL4222914 | 0.81 | HSD11B1 (0.60) | HSD11B1MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL4227413 | 0.80 | GRM5 (0.57) | HSD11B1MEN1KMT2ATSHRGRM5 | |
| SCHEMBL4233373 | 0.80 | HSD11B1 (0.61) | HSD11B1MEN1KMT2AALDH1A1LMNA | |
| SCHEMBL4229033 | 0.80 | HSD11B1 (0.61) | HSD11B1GRM5CLPPSCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893606-A2 | SUBSTITUTED OXADIAZOLE DERIVATIVES AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Addex Pharma SA (CH) | 2008-03-05 | — | — | EP | claimed |
| WO-2006123255-A2 | SUBSTITUTED OXADIAZOLE DERIVATIVES AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX PHARMA SA (CH) | 2006-11-23 | — | — | WO | claimed |