Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.36 |
| ▸ | MEN1 | O00255 | 5/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3538669 | 0.82 | HTT (0.39) | HTTALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL3531473 | 0.81 | HTT (0.38) | HTTALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL3532841 | 0.81 | HTT (0.38) | HTTALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL3531827 | 0.80 | ALDH1A1 (0.42) | HTTALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL3534757 | 0.80 | ALDH1A1 (0.43) | HTTALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL1814309 | 0.80 | ALDH1A1 (0.43) | HTTALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL4635823 | 0.79 | ALDH1A1 (0.54) | ALDH1A1KMT2AMEN1NPY5RL3MBTL1 | |
| SCHEMBL3531630 | 0.77 | CA12 (0.45) | HTTALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL3535790 | 0.76 | CA12 (0.40) | HTTALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL3531657 | 0.76 | KMT2A (0.50) | HTTALDH1A1KMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1931640-A2 | SUBSTITUTED-3-SULFONYLINDAZOLE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | Wyeth a Corporation of the State of Delaware (US) | 2008-06-18 | — | — | EP | disclosed |
| WO-2007021711-A2 | SUBSTITUTED-3-SULFONYLINDAZOLE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | WYETH (US) | 2007-02-22 | — | — | WO | disclosed |