Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL438423 | 0.79 | LMNA (0.60) | MAPTALDH1A1CYP1A2CYP2C19L3MBTL1 | |
| SCHEMBL405824 | 0.79 | TSHR (0.49) | MAPTALDH1A1CYP1A2CYP2C19L3MBTL1 | |
| SCHEMBL405334 | 0.79 | ALDH1A1 (0.43) | MAPTALDH1A1CYP1A2CYP2C19L3MBTL1 | |
| SCHEMBL406583 | 0.79 | LMNA (0.60) | MAPTALDH1A1CYP1A2CYP2C19L3MBTL1 | |
| SCHEMBL12246126 | 0.78 | MAPT (0.44) | MAPTALDH1A1CYP1A2CYP2C19L3MBTL1 | |
| SCHEMBL8533307 | 0.76 | ALDH1A1 (0.62) | MAPTALDH1A1CYP1A2CYP2C19L3MBTL1 | |
| SCHEMBL6194046 | 0.76 | ALDH1A1 (0.62) | MAPTALDH1A1CYP1A2CYP2C19L3MBTL1 | |
| SCHEMBL30603181 | 0.76 | ALDH1A1 (0.62) | MAPTALDH1A1CYP1A2CYP2C19L3MBTL1 | |
| SCHEMBL618724 | 0.76 | TDP1 (0.44) | MAPTALDH1A1CYP1A2CYP2C19L3MBTL1 | |
| SCHEMBL621774 | 0.76 | TDP1 (0.44) | MAPTALDH1A1CYP1A2CYP2C19L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120065187-A1 | HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE | ALCON RESEARCH, LTD (US) | 2012-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120065187-A1 | HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE | HRH4, HRH3, HRH2 | MAPT 2336/4885ALDH1A1 1909/4885CYP1A2 2609/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.