Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 13/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | EDNRA | P25101 | 1/20 | 0.60 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.60 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.60 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4636559 | 0.85 | ALDH1A1 (0.67) | SCN9AALDH1A1LMNAKDM4ECYP2C9 | |
| SCHEMBL326633 | 0.78 | ALDH1A1 (0.71) | SCN9AALDH1A1LMNAKDM4ECYP2C9 | |
| SCHEMBL1576454 | 0.77 | ALDH1A1 (0.66) | SCN9AALDH1A1LMNAKDM4ECYP2C9 | |
| SCHEMBL1576300 | 0.77 | ALDH1A1 (0.66) | SCN9AALDH1A1LMNAKDM4ECYP2C9 | |
| Hydrochloric Acid SCHEMBL27575105 | 0.77 | ALDH1A1 (0.69) | SCN9AALDH1A1LMNAKDM4ECYP2C9 | |
| SCHEMBL328567 | 0.77 | ALDH1A1 (0.61) | SCN9AALDH1A1LMNAKDM4ECYP2C9 | |
| SCHEMBL9301181 | 0.77 | ALDH1A1 (0.69) | SCN9AALDH1A1LMNAKDM4ECYP2C9 | |
| SCHEMBL3070565 | 0.76 | ALDH1A1 (0.68) | SCN9AALDH1A1LMNAKDM4ECYP2C9 | |
| SCHEMBL16530980 | 0.76 | SCN9A (1.00) | SCN9A | |
| SCHEMBL16530789 | 0.76 | SCN9A (1.00) | SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1934191-A2 | BIPHENYL DERIVATIVES AS MODULATORS OF VOLTAGE GATED ION CHANNELS | Vertex Pharmaceuticals, Inc. (US) | 2008-06-25 | — | — | EP | disclosed |
| WO-2007047474-A2 | BIPHENYL DERIVATIVES AS MODULATORS OF VOLTAGE GATED ION CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-04-26 | — | — | WO | disclosed |