Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 5/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | PTPRC | P08575 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27680682 | 0.86 | KMT2A (0.41) | MAPTKMT2AALDH1A1HTTGAA | |
| SCHEMBL27830742 | 0.80 | KMT2A (0.41) | MAPTKMT2AALDH1A1HTTGAA | |
| SCHEMBL11027684 | 0.78 | BCL9 (0.40) | MAPTKMT2AALDH1A1HTTGAA | |
| SCHEMBL9351950 | 0.77 | GSK3B (0.41) | MAPTKMT2AGAATDP1PKM | |
| SCHEMBL10587921 | 0.77 | KMT2A (0.37) | MAPTKMT2AALDH1A1GAATDP1 | |
| SCHEMBL3671086 | 0.77 | KMT2A (0.33) | MAPTKMT2AALDH1A1TDP1MEN1 | |
| SCHEMBL10369277 | 0.75 | KDM4E (0.33) | MAPTKMT2AALDH1A1GAATDP1 | |
| SCHEMBL4634541 | 0.75 | KMT2A (0.36) | MAPTKMT2AALDH1A1TDP1MEN1 | |
| SCHEMBL3418797 | 0.75 | POLB (0.40) | MAPTKMT2AALDH1A1GAATDP1 | |
| SCHEMBL17629372 | 0.75 | MAPT (0.33) | MAPTKMT2AALDH1A1HTTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1742925-B1 | SUBSTITUTED 5, 6, 7, 8-TETRAHYDRO-PYRIDO[4, 3-D]PYRIMIDINE-2-YL COMPOUNDS AND 5, 6, 7, 8-TETRAHYDRO-QUINAZOLINE-2-YL COMPOUNDS | GRUENENTHAL GMBH (DE) | 2014-04-23 | — | — | EP | disclosed |
| EP-1937271-A1 | MICROANGIOPATHY TREATMENT AND PREVENTION | Bayer HealthCare AG (DE) | 2008-07-02 | — | — | EP | disclosed |
| EP-1933841-A1 | COMBINATION THERAPY COMPRISING SUBSTITUTED OXAZOLIDINONES FOR THE PREVENTION AND TREATMENT OF CEREBRAL CIRCULATORY DISORDERS | Bayer HealthCare AG (DE) | 2008-06-25 | — | — | EP | disclosed |
| WO-2007042146-A1 | MICROANGIOPATHY TREATMENT AND PREVENTION | BAYER HEALTHCARE AG (DE) | 2007-04-19 | — | — | WO | disclosed |
| WO-2007039134-A1 | COMBINATION THERAPY COMPRISING SUBSTITUTED OXAZOLIDINONES FOR THE PREVENTION AND TREATMENT OF CEREBRAL CIRCULATORY DISORDERS | BAYER HEALTHCARE AG (DE) | 2007-04-12 | — | — | WO | disclosed |
| EP-1742925-A1 | SUBSTITUTED 5, 6, 7, 8-TETRAHYDRO-PYRIDO[4, 3-D]PYRIMIDINE-2-YL COMPOUNDS AND 5, 6, 7, 8-TETRAHYDRO-QUINAZOLINE-2-YL COMPOUNDS | Grünenthal GmbH (DE) | 2007-01-17 | — | — | EP | disclosed |
| WO-2005105759-A1 | SUBSTITUTED 5, 6, 7, 8-TETRAHYDRO-PYRIDO[4, 3-D]PYRIMIDINE-2-YL COMPOUNDS AND 5, 6, 7, 8-TETRAHYDRO-QUINAZOLINE-2-YL COMPOUNDS | Grünenthal GmbH (DE) | 2005-11-10 | — | — | WO | disclosed |
| EP-0589301-A1 | Carboxynilides derivatives, process for their preparation and fungicidal compositions containing them | BASF Aktiengesellschaft (DE) | 1994-03-30 | — | — | EP | disclosed |
| EP-0321857-B1 | Process for preparing aromatic hydroxycarboxylic acids | BASF AG (DE) | 1994-03-30 | — | — | EP | disclosed |
| EP-0379003-A1 | Thiophene-2-carboxylic-acid derivatives, process for their preparation and their use in combating undesired plant growth | BASF Aktiengesellschaft (DE) | 1990-07-25 | — | — | EP | disclosed |
| EP-0328766-A1 | Process for the preparation of aromatic dicarboxylic acids | BASF Aktiengesellschaft (DE) | 1989-08-23 | — | — | EP | disclosed |
| EP-0321857-A2 | Process for preparing aromatic hydroxycarboxylic acids | BASF Aktiengesellschaft (DE) | 1989-06-28 | — | — | EP | disclosed |
| EP-0216279-B1 | PROCESS FOR THE PREPARATION OF HALOGEN-THIOPHENE-2-CARBOXYLIC ACIDS | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-05-24 | — | — | EP | disclosed |
| EP-0216279-A1 | Process for the preparation of halogen-thiophene-2-carboxylic acids | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-04-01 | — | — | EP | disclosed |