Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | TDO2 | P48775 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA7 | P43166 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27703251 | 0.86 | POLB (0.39) | POLBMAPTNPSR1NPC1PKM | |
| SCHEMBL9409748 | 0.82 | CUL4A (0.37) | POLBMAPTNPSR1NPC1PKM | |
| SCHEMBL28341914 | 0.81 | KMT2A (0.40) | POLBMAPTNPSR1NPC1PKM | |
| SCHEMBL9351950 | 0.77 | GSK3B (0.41) | POLBMAPTNPC1PKMRAB9A | |
| SCHEMBL10587921 | 0.77 | KMT2A (0.37) | POLBMAPTRAB9ALMNAALDH1A1 | |
| SCHEMBL3671086 | 0.77 | KMT2A (0.33) | POLBMAPTNPSR1NPC1RAB9A | |
| SCHEMBL4636562 | 0.75 | MAPT (0.40) | POLBMAPTNPSR1PKMLMNA | |
| SCHEMBL4634541 | 0.75 | KMT2A (0.36) | POLBMAPTNPC1RAB9ALMNA | |
| SCHEMBL10369277 | 0.75 | KDM4E (0.33) | POLBMAPTLMNAALDH1A1KMT2A | |
| SCHEMBL17629372 | 0.75 | MAPT (0.33) | POLBMAPTPKMRAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2149551-A1 | N-(indol-3-ylalkyl)-(hetero)arylamid derivatives as modulators of EP2 receptors | Bayer Schering Pharma AG (DE) | 2010-02-03 | — | — | EP | claimed |
| EP-2002834-A1 | Aryl and hetaryl amides as modulators of EP2 receptors | Bayer Schering Pharma Aktiengesellschaft (DE) | 2008-12-17 | — | — | EP | disclosed |