Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 3/20 | 0.62 |
| ▸ | CCR3 | P51677 | 1/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.55 |
| ▸ | DRD4 | P21917 | 2/20 | 0.53 |
| ▸ | DRD2 | P14416 | 1/20 | 0.53 |
| ▸ | DRD3 | P35462 | 1/20 | 0.53 |
| ▸ | MC4R | P32245 | 1/20 | 0.51 |
| ▸ | BCHE | P06276 | 1/20 | 0.51 |
| ▸ | BACE1 | P56817 | 1/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.50 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL537414 | 0.90 | ACHE (0.54) | ACHECCR3SIGMAR1DRD4DRD2 | |
| SCHEMBL2676077 | 0.90 | ACHE (0.54) | ACHECCR3SIGMAR1DRD4DRD2 | |
| SCHEMBL4884981 | 0.90 | ACHE (0.54) | ACHECCR3SIGMAR1DRD4DRD2 | |
| SCHEMBL2676079 | 0.90 | ACHE (0.54) | ACHECCR3SIGMAR1DRD4DRD2 | |
| SCHEMBL22254437 | 0.87 | POLB (0.53) | ACHELMNAPOLB | |
| SCHEMBL7952371 | 0.86 | ACHE (0.66) | ACHECCR3SIGMAR1DRD4DRD2 | |
| SCHEMBL22255094 | 0.85 | LMNA (0.56) | ACHESIGMAR1DRD4LMNA | |
| SCHEMBL7852368 | 0.85 | ACHE (0.64) | ACHECCR3SIGMAR1DRD4DRD2 | |
| SCHEMBL7651915 | 0.83 | ACHE (0.62) | ACHECCR3SIGMAR1DRD4DRD2 | |
| SCHEMBL20012633 | 0.83 | ACHE (0.62) | ACHECCR3SIGMAR1DRD4DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1934187-A1 | NOVEL BENZIMIDAZOLE AND BENZOTHIAZOLE DERIVATIVES, METHOD FOR PREPARING SAME, USE THEREOF AS DRUGS, PHARMACEUTICAL COMPOSITIONS AND NOVEL USE IN PARTICULAR AS C-MET INHIBITORS | Aventis Pharma S.A. (FR) | 2008-06-25 | — | — | EP | disclosed |
| WO-2007036630-A1 | NOVEL BENZIMIDAZOLE AND BENZOTHIAZOLE DERIVATIVES, METHOD FOR PREPARING SAME, USE THEREOF AS DRUGS, PHARMACEUTICAL COMPOSITIONS AND NOVEL USE IN PARTICULAR AS C-MET INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2007-04-05 | — | — | WO | disclosed |
| EP-0673927-B1 | piperidines as anticholinergic agents | EISAI CO LTD (JP) | 2001-09-19 | — | — | EP | disclosed |
| EP-1116716-A1 | Piperidine and piperazine compounds for use in the treatment of Alzheimer | Eisai Co., Ltd. (JP) | 2001-07-18 | — | — | EP | disclosed |
| EP-0481429-B1 | Quinoline derivatives | SS PHARMACEUTICAL CO (JP) | 2001-01-24 | — | — | EP | disclosed |
| EP-0987262-A1 | Quinoline derivatives | SS PHARMACEUTICAL CO., LTD. (JP) | 2000-03-22 | — | — | EP | disclosed |
| EP-0579263-B1 | 1,4-Substituted piperidines as acetylchozinesterase inhibitors and their use for the treatment of Alzheimer's disease | EISAI CO LTD (JP) | 1998-09-16 | — | — | EP | disclosed |
| US-5654306-A | ALZHEIMER'S DISEASE; COGNITION ACTIVATORS; BRAIN AND PSYCHOLOGICAL DISORDERS | EISAI CO., LTD. (JP) | 1997-08-05 | — | — | US | disclosed |
| EP-0742207-A1 | 2-(Indan-1-one-2-yl-alkyl)-1-phenylalkyl-piperidines and processes for their preparation | Eisai Co., Ltd. (JP) | 1996-11-13 | — | — | EP | disclosed |
| EP-0673927-A1 | 4-[2-indanyl-1-one]alkylpiperidines as anticholinergic agents | Eisai Co., Ltd. (JP) | 1995-09-27 | — | — | EP | disclosed |
| EP-0229391-B1 | PIPERIDINE DERIVATE, ITS USE AND PHARMACEUTICAL COMPOSITION CONTAINING IT | Eisai Co., Ltd. (JP) | 1992-07-29 | — | — | EP | disclosed |
| US-5118684-A | For cardiovascular disorder | EISAI CO., LTD. (JP) | 1992-06-02 | — | — | US | disclosed |
| EP-0481429-A2 | Quinoline derivatives | SS PHARMACEUTICAL CO., LTD. (JP) | 1992-04-22 | — | — | EP | disclosed |
| US-5100901-A | Treatment of Alzheimer*s disease | EISAI CO., LTD. (JP) | 1992-03-31 | — | — | US | disclosed |
| US-5039681-A | Cognition activators, brain disorders, psychology | EISAI CO., LTD. (JP) | 1991-08-13 | — | — | US | disclosed |
| US-4942169-A | COGNITION ACTIVATORS, ANTICHOLINESTERASE | EISAI CO., LTD. (JP) | 1990-07-17 | — | — | US | disclosed |
| US-4895841-A | Cyclic amine compounds with activity against acetylcholinesterase | EISAI CO., LTD. (JP) | 1990-01-23 | — | — | US | disclosed |
| US-4849431-A | ANTICHOLINESTERASE ACTIVITY | EISAI CO., LTD. (JP) | 1989-07-18 | — | — | US | disclosed |
| EP-0296560-A2 | 1,4-Substituted piperidines as acetylcholinesterase inhibitors and their use for the treatment of Alzheimer's disease | Eisai Co., Ltd. (JP) | 1988-12-28 | — | — | EP | disclosed |
| EP-0229391-A1 | Piperidine derivate, its use and pharmaceutical composition containing it | Eisai Co., Ltd. (JP) | 1987-07-22 | — | — | EP | disclosed |