SCHEMBL4636735

SCHEMBL4636735

O=C=NC(=O)c1cccc(F)c1F

nearest known ligand 0.57

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CES2 O00748 6/20 0.57
CES1 P23141 6/20 0.57
BCHE P06276 1/20 0.57
HPGD P15428 2/20 0.45
ALB P02768 1/20 0.40
KAT6A Q92794 2/20 0.39
ALDH1A1 P00352 2/20 0.38
ALOX15 P16050 1/20 0.38
ATM Q13315 1/20 0.36
PTPN1 P18031 1/20 0.36
ERCC5 P28715 1/20 0.36
FEN1 P39748 1/20 0.36
GAA P10253 1/20 0.35
MEN1 O00255 1/20 0.34
KMT2A Q03164 1/20 0.34
TDP1 Q9NUW8 1/20 0.34
SLC9A1 P19634 1/20 0.34
NPC1 O15118 1/20 0.33
MAPT P10636 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4145212 0.85 CES2 (0.54) CES2CES1BCHEHPGDKAT6A
SCHEMBL28016424 0.84 CES2 (0.55) CES2CES1BCHEHPGDALB
SCHEMBL6424083 0.82 KAT6A (0.41) CES2CES1BCHEHPGDKAT6A
SCHEMBL4141953 0.79 CES2 (0.52) CES2CES1BCHEALBGAA
SCHEMBL3395153 0.78 ALDH1A1 (0.42) CES2CES1HPGDALDH1A1ALOX15
SCHEMBL34472768 0.76 NR4A1 (0.38) CES2CES1BCHEHPGDALDH1A1
SCHEMBL3440833 0.73 CES2 (0.74) CES2CES1BCHEHPGDALB
SCHEMBL3184940 0.73 CES2 (1.00) CES2CES1BCHEHPGDALB
SCHEMBL11274036 0.71 CES2 (0.44) CES2CES1HPGDALDH1A1MEN1
SCHEMBL10991228 0.71 CES2 (0.44) CES2CES1GAAMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 62 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1267402-C Synthetic method for 3,5-dichloro-2,4-difluoronitrobenzene and teflubenzuron UNIV ZHEJIANG TECHNOLOGY (CN) 2006-08-02 CN claimed
CN-1683318-A Synthetic method for 3,5-dichloro-2,4-difluoronitrobenzene and teflubenzuron UNIV ZHEJIANG POLYTECHNIC (CN) 2005-10-19 CN claimed
CN-1218935-C Substituted benzoyl urea insect growth regulator synthesizing method INST ZOOLOGY CAS (CN) 2005-09-14 CN claimed
CN-106748985-A A kind of synthetic method of chlorfluazuron and its purposes for preparing insecticide 山东东方农药科技实业有限公司 2017-05-31 CN disclosed
CN-104062367-B A kind of by normal phase high performance liquid chromatography Direct Analysis 1, the method for 5-naphthalene diisocyanate content XIANGTAN UNIVERSITY (CN) 2016-05-11 CN disclosed
CN-104062367-A Method for directly analyzing content of 1,5-naphthalene diisocyanate by normal-phase high performance liquid chromatography UNIV XIANGTAN 2014-09-24 CN disclosed
CN-103214400-A Preparation method of hexaflumuron UNIV QUZHOU 2013-07-24 CN disclosed
CN-102702031-A 2'-chloro-hexafluoroisopropylbenzoylurea compound and use thereof UNIV EAST CHINA SCIENCE & TECH 2012-10-03 CN disclosed
CN-101538227-B Compound containing sevoflurane isopropyl benzoyl urea and application thereof UNIV EAST CHINA SCIENCE & TECH 2012-06-06 CN disclosed
CN-101357909-B 1,3, 4-thiadiazole aroyl urea compound and preparation method and application thereof NANJING UNIVERSITY OF TECHNOLOGY 2011-06-15 CN disclosed
CN-101538227-A Compound containing sevoflurane isopropyl benzoyl urea and application thereof UNIV EAST CHINA SCIENCE & TECH 2009-09-23 CN disclosed
EP-0228846-A1 Amino-trifluoromethylpyridine compound and process for preparing the same ISHIHARA SANGYO KAISHA, LTD. (JP) 1987-07-15 EP disclosed
EP-0226642-A1 BENZOYLUREA DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND INSECTICIDES NIPPON SODA CO., LTD. (JP) 1987-07-01 EP disclosed
CN-86106647-A Benzoylphenylurea 1987-07-01 CN disclosed
CN-85106730-A Process for preparation of benzoylurea compounds 1987-03-25 CN disclosed
CN-86106424-A The benzoyl urea compounds that insecticidal action is arranged 1987-03-25 CN disclosed
CN-86101870-A The preparation and the application thereof of novel benzoyl area kind 1987-01-21 CN disclosed
CN-85104628-A Production and use of benzoylureas 1986-12-10 CN disclosed
CN-85108797-A A kind of preparation method of new benzoylphenylurea derivative and as the application of sterilant 1986-09-24 CN disclosed
CN-86100630-A Preparation contains the method for the sterilant of acylurea 1986-09-03 CN disclosed