Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 9/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.43 |
| ▸ | TNF | P01375 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4637157 | 0.91 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL4637296 | 0.82 | PDE4A (0.67) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL4637927 | 0.79 | PDE4B (0.52) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL4637199 | 0.79 | TNF (0.67) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL4637277 | 0.78 | PDE4B (0.58) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL4728355 | 0.77 | PDE4B (0.56) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL4637250 | 0.76 | PDE4B (0.51) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL4671897 | 0.76 | ACHE (0.59) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL30540379 | 0.76 | ACHE (0.59) | PDE4APDE4BPDE4CPDE4DTNF | |
| SCHEMBL2991798 | 0.76 | ACHE (0.59) | PDE4APDE4BPDE4CPDE4DTNF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1468991-B1 | Imides as PDE III, PDE IV and TNF inhibitors | CELGENE CORP (US) | 2008-02-20 | — | — | EP | disclosed |
| EP-1468991-A1 | Imides as PDE III, PDE IV and TNF inhibitors | CELGENE CORPORATION (US) | 2004-10-20 | — | — | EP | disclosed |
| EP-0874819-B1 | IMIDES AS PDE III, PDE IV AND TNF INHIBITORS | CELGENE CORP (US) | 2004-05-26 | — | — | EP | disclosed |
| EP-0874819-A1 | IMIDES AS PDE III, PDE IV AND TNF INHIBITORS | CELGENE CORPORATION (US) | 1998-11-04 | — | — | EP | disclosed |
| WO-1997023457-A1 | IMIDES AS PDE III, PDE IV AND TNF INHIBITORS | CELGENE CORPORATION (US) | 1997-07-03 | — | — | WO | disclosed |