Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 13/20 | 0.56 |
| ▸ | PDE4A | P27815 | 11/20 | 0.56 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.56 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.49 |
| ▸ | TNF | P01375 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4727275 | 0.90 | PDE4B (0.55) | PDE4BPDE4APDE4CPDE4DTNF | |
| SCHEMBL2995451 | 0.85 | PDE4A (0.62) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL4637671 | 0.84 | PDE4A (0.61) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL6231659 | 0.82 | FFAR1 (0.55) | PDE4BPDE4APDE4CPDE4DFFAR1 | |
| SCHEMBL2991798 | 0.81 | ACHE (0.59) | PDE4BPDE4APDE4CPDE4DTNF | |
| SCHEMBL30540379 | 0.81 | ACHE (0.59) | PDE4BPDE4APDE4CPDE4DTNF | |
| SCHEMBL5720955 | 0.81 | ACHE (0.59) | PDE4BPDE4APDE4CPDE4DTNF | |
| SCHEMBL4671897 | 0.81 | ACHE (0.59) | PDE4BPDE4APDE4CPDE4DTNF | |
| SCHEMBL4637223 | 0.80 | PDE4A (0.80) | PDE4BPDE4APDE4CPDE4DTNF | |
| SCHEMBL2985100 | 0.80 | PDE4A (0.57) | PDE4BPDE4APDE4CPDE4DFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1468991-B1 | Imides as PDE III, PDE IV and TNF inhibitors | CELGENE CORP (US) | 2008-02-20 | — | — | EP | disclosed |
| EP-1468991-A1 | Imides as PDE III, PDE IV and TNF inhibitors | CELGENE CORPORATION (US) | 2004-10-20 | — | — | EP | disclosed |
| US-5728844-A | INHIBITORS OF TUMOR NECROSIS AND PHOSPHODIESTERASE | CELGENE CORPORATION (US) | 1998-03-17 | — | — | US | disclosed |