Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 5/20 | 0.40 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 3/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4637479 | 0.88 | PTGDR2 (0.41) | PTGDR2EPAS1ALDH1A1MAPTTHRB | |
| SCHEMBL4637426 | 0.85 | PTGDR2 (0.42) | PTGDR2EPAS1ALDH1A1MAPTBRD4 | |
| SCHEMBL4782137 | 0.84 | PTGDR2 (0.40) | PTGDR2EPAS1ALDH1A1LMNAHTT | |
| SCHEMBL4637399 | 0.78 | EPAS1 (0.47) | PTGDR2EPAS1ALDH1A1BRD4SOS1 | |
| SCHEMBL4638438 | 0.77 | PTGDR2 (0.45) | PTGDR2BRD4RORC | |
| SCHEMBL3927504 | 0.77 | ALDH1A1 (0.42) | PTGDR2EPAS1ALDH1A1BRD4SLC6A2 | |
| SCHEMBL3927507 | 0.76 | ALDH1A1 (0.44) | PTGDR2EPAS1ALDH1A1BRD4SLC6A2 | |
| SCHEMBL4876608 | 0.76 | ALDH1A1 (0.41) | PTGDR2EPAS1ALDH1A1BRD4SLC6A2 | |
| SCHEMBL4638354 | 0.76 | EPAS1 (0.46) | EPAS1RORC | |
| SCHEMBL4639087 | 0.75 | EPAS1 (0.44) | PTGDR2EPAS1ALDH1A1SMN1; SMN2SOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937632-A1 | NOVEL COMPOUNDS | Astra Zeneca AB (SE) | 2008-07-02 | — | — | EP | claimed |
| WO-2007039736-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2007-04-12 | — | — | WO | claimed |
| EP-1937632-A1 | NOVEL COMPOUNDS | Astra Zeneca AB (SE) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007039736-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2007-04-12 | — | — | WO | disclosed |