Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 8/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | CCR2 | P41597 | 3/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 5/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4638189 | 0.88 | EPAS1 (0.39) | PTGDR2BRD4CCR2NR1H2NR1H3 | |
| SCHEMBL4637479 | 0.85 | PTGDR2 (0.41) | PTGDR2BRD4RORCPOLBL3MBTL1 | |
| SCHEMBL4637426 | 0.84 | PTGDR2 (0.42) | PTGDR2BRD4RORC | |
| SCHEMBL4638354 | 0.80 | EPAS1 (0.46) | RORC | |
| SCHEMBL4637511 | 0.77 | PTGDR2 (0.40) | PTGDR2BRD4RORC | |
| SCHEMBL2065425 | 0.76 | PTGDR2 (0.52) | PTGDR2RORC | |
| SCHEMBL4638324 | 0.75 | KIF11 (0.43) | BRD4 | |
| SCHEMBL14632300 | 0.74 | CCR2 (0.60) | PTGDR2CCR2POLBL3MBTL1 | |
| SCHEMBL4782137 | 0.73 | PTGDR2 (0.40) | PTGDR2BRD4POLBL3MBTL1 | |
| SCHEMBL4637412 | 0.72 | PTGS2 (0.43) | PTGDR2BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937632-A1 | NOVEL COMPOUNDS | Astra Zeneca AB (SE) | 2008-07-02 | — | — | EP | claimed |
| WO-2007039736-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2007-04-12 | — | — | WO | claimed |
| EP-1937632-A1 | NOVEL COMPOUNDS | Astra Zeneca AB (SE) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007039736-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2007-04-12 | — | — | WO | disclosed |