SCHEMBL463754

SCHEMBL463754

Clc1cc(Cl)cc(-c2cc(Cl)cc(Cl)c2)c1

nearest known ligand 0.73

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.73
CYP3A4 P08684 2/20 0.50
TP53 P04637 1/20 0.50
RXRA P19793 2/20 0.48
RXRB P28702 2/20 0.48
ALDH1A1 P00352 3/20 0.44
CHKA P35790 1/20 0.41
AHR P35869 3/20 0.40
GFER P55789 1/20 0.40
RXFP1 Q9HBX9 1/20 0.40
TPMT P51580 1/20 0.40
TTR P02766 1/20 0.39
RECQL P46063 1/20 0.39
HSD17B10 Q99714 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
ASIC3 Q9UHC3 1/20 0.38
MAP4K4 O95819 1/20 0.37
IDO1 P14902 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Water SCHEMBL11490326 0.96 TSHR (0.67) TSHRCYP3A4TP53RXRARXRB
Hydrogen Sulfide SCHEMBL11473568 0.96 TSHR (0.67) TSHRCYP3A4TP53RXRARXRB
SCHEMBL1958364 0.89 RXRA (0.61) TSHRCYP3A4TP53RXRARXRB
1,3,5-Trichlorobenzene SCHEMBL429512 0.85
SCHEMBL463584 0.83 AHR (0.65) TSHRCYP3A4TP53RXRARXRB
SCHEMBL4246853 0.83 AHR (0.62) TSHRRXRARXRBALDH1A1CHKA
SCHEMBL1959838 0.80 RXRA (0.59) TSHRCYP3A4RXRARXRBCHKA
SCHEMBL308200 0.80 CYP1A2 (0.60) TSHRTP53RXRARXRBALDH1A1
SCHEMBL13538918 0.80 TSHR (0.47) TSHRCYP3A4TP53RXRARXRB
1,3,5-Trichlorobenzene SCHEMBL29043929 0.80 TSHR (0.89) TSHRCYP3A4TP53ALDH1A1AHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119931270-A High-adhesion low-moisture-absorption solid epoxy molding compound and preparation method and application thereof 安庆兴凯半导体材料有限公司 2025-05-06 CN claimed
CN-114014934-B Polychlorinated biphenyl monoclonal antibody and application thereof 江苏省农业科学院 2023-05-05 CN claimed
EP-4160211-A1 DETECTING THE EXPOSURE OF A SUBJECT TO A THYROID DISRUPTING CHEMICAL, EVEN BEFORE HYPOTHYROIDISM APPEARS Moreno Navarro, José Carlos (ES) 2023-04-05 EP claimed
EP-3881907-A1 METHOD FOR DECHLORINATION OF ONE OR MORE AROMATIC ORGANOCHLORINE COMPOUND(S) CONTAINED IN AN OIL OR FORMING SAID OIL - ASSOCIATED ELECTRICAL/ELECTRONIC DEVICE AND INSTALLATION Université de Lille (FR) 2021-09-22 EP claimed
CN-119931270-A High-adhesion low-moisture-absorption solid epoxy molding compound and preparation method and application thereof 安庆兴凯半导体材料有限公司 2025-05-06 CN disclosed
WO-2024235507-A1 METHOD FOR PRODUCING A POLYMER, IN PARTICULAR FOR A MEMBRANE, POLYMER, MEMBRANE AND USE OF A MEMBRANE Forschungszentrum Jülich GmbH (DE) 2024-11-21 WO disclosed
CN-222011091-U Manual-automatic integrated rotating structure and water valve 福建天成宝得智能科技有限公司 2024-11-15 CN disclosed
WO-2024160834-A1 METHOD FOR PRODUCING A POLYMER, IN PARTICULAR FOR A MEMBRANE, POLYMER, MEMBRANE AND USE OF A MEMBRANE Forschungszentrum Jülich GmbH (DE) 2024-08-08 WO disclosed
US-20240226160-A9 ACTIVITY-INDUCIBLE FUSION PROTEINS HAVING A HEAT SHOCK PROTEIN 90 BINDING DOMAIN SEATTLE CHILDREN'S HOSPITAL D/B/A SEATTLE CHILDREN'S RESEARCH INSTITUTE (US) 2024-07-11 US disclosed
CN-117147725-B Method for measuring polychlorinated biphenyl content and total amount in sample by adopting quantitative ion abundance compensation mode 四川省生态环境监测总站 2024-04-26 CN disclosed
US-20240131072-A1 ACTIVITY-INDUCIBLE FUSION PROTEINS HAVING A HEAT SHOCK PROTEIN 90 BINDING DOMAIN SEATTLE CHILDREN'S HOSPITAL D/B/A SEATTLE CHILDREN'S RESEARCH INSTITUTE (US) 2024-04-25 US disclosed
CN-111448192-B Process for preparing anthelmintic 4-amino-quinoline-3-carboxamide derivatives 拜耳动物保健有限责任公司 2024-04-12 CN disclosed
US-20100129729-A1 CEOSSLINKED AROMATIC POLYMER, POLYMER ELECTROLYTE,CATALYST INK, POLYMER ELECTROLYTE MEMBRANE, MEMBRANE-ELECTRODE ASSEMBLY AND FUEL CELL SUMITOMO CHEMICAL COMPANY ,LIMITED 2010-05-27 US disclosed
US-20100129729-A1 CEOSSLINKED AROMATIC POLYMER, POLYMER ELECTROLYTE,CATALYST INK, POLYMER ELECTROLYTE MEMBRANE, MEMBRANE-ELECTRODE ASSEMBLY AND FUEL CELL SUMITOMO CHEMICAL COMPANY ,LIMITED 2010-05-27 US disclosed
US-20100120919-A1 METHODS FOR TREATING TRANSTHYRETIN AMYLOID DISEASES NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2010-05-13 US disclosed
US-20090269857-A1 Instruments for detecting low-molecular weight substance FUJIKURA KASEI CO., LTD. (JP) 2009-10-29 US disclosed
US-20050148097-A1 Instruments for detecting low-molecular weight substance ENBIOTEC LABORATORIES C., LTD. (JP) 2005-07-07 US disclosed
EP-1489420-A1 INSTRUMENTS FOR DETECTING LOW-MOLECULAR WEIGHT SUBSTANCE Enbiotec Laboratories Co., Ltd. (JP) 2004-12-22 EP disclosed
US-4876201-A CULTURING WITH ALCALIGENES UNDER AEROBIC CONDITIONS GENERAL ELECTRIC COMPANY (US) 1989-10-24 US disclosed
US-4843007-A AEROBIC TREATMENT GENERAL ELECTRIC COMPANY (US) 1989-06-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100120919-A1 METHODS FOR TREATING TRANSTHYRETIN AMYLOID DISEASES TTR, TTPA, PRNP TSHR 1892/4885CYP3A4 4110/4885TP53 712/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.