Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPAS1 | Q99814 | 4/20 | 0.55 |
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | NR1H2 | P55055 | 8/20 | 0.45 |
| ▸ | NR1H3 | Q13133 | 8/20 | 0.45 |
| ▸ | AR | P10275 | 1/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.44 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10884180 | 0.81 | EPAS1 (0.46) | EPAS1NR1H2NR1H3PTGS1PTGS2 | |
| SCHEMBL2065914 | 0.77 | PTGDR2 (0.49) | EPAS1RXRA | |
| SCHEMBL10882410 | 0.77 | EPAS1 (0.43) | EPAS1NR1H2NR1H3PTGS1PTGS2 | |
| SCHEMBL4637515 | 0.73 | EPAS1 (0.45) | EPAS1BRD4NR1H2NR1H3PTGS1 | |
| SCHEMBL2394875 | 0.73 | PTGDR2 (0.48) | — | |
| SCHEMBL4638189 | 0.72 | EPAS1 (0.39) | EPAS1BRD4NR1H2NR1H3PTGS1 | |
| SCHEMBL27866124 | 0.72 | PTGDR2 (0.44) | EPAS1 | |
| SCHEMBL1651701 | 0.72 | EPAS1 (0.41) | EPAS1NR1H2NR1H3 | |
| SCHEMBL1460007 | 0.72 | KIF11 (0.45) | EPAS1NR1H2NR1H3PTGS1PTGS2 | |
| SCHEMBL5831491 | 0.72 | SLC6A4 (0.41) | EPAS1BRD4NR1H2NR1H3PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937632-A1 | NOVEL COMPOUNDS | Astra Zeneca AB (SE) | 2008-07-02 | — | — | EP | claimed |
| WO-2007039736-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2007-04-12 | — | — | WO | claimed |