Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPAS1 | Q99814 | 11/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | VEGFA | P15692 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4638324 | 0.78 | KIF11 (0.43) | EPAS1KIF11ALOX5APFEN1BRD4 | |
| SCHEMBL2067362 | 0.75 | NR3C1 (0.50) | EPAS1PTGS2 | |
| SCHEMBL10884180 | 0.74 | EPAS1 (0.46) | EPAS1KIF11ALOX5APFEN1NR1H2 | |
| SCHEMBL4638189 | 0.74 | EPAS1 (0.39) | EPAS1KIF11ALOX5APFEN1NR1H2 | |
| SCHEMBL4637544 | 0.73 | EPAS1 (0.55) | EPAS1NR1H2NR1H3BRD4PTGS2 | |
| SCHEMBL4637444 | 0.73 | EPAS1 (0.53) | EPAS1SLC6A4BRD4PTGS2PTGS1 | |
| SCHEMBL16555665 | 0.72 | EPAS1 (0.67) | EPAS1VEGFA | |
| SCHEMBL4638321 | 0.72 | PLA2G7 (0.40) | EPAS1VEGFA | |
| SCHEMBL1460007 | 0.71 | KIF11 (0.45) | EPAS1KIF11ALOX5APFEN1NR1H2 | |
| SCHEMBL5831491 | 0.71 | SLC6A4 (0.41) | EPAS1SLC6A4KIF11ALOX5APFEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937632-A1 | NOVEL COMPOUNDS | Astra Zeneca AB (SE) | 2008-07-02 | — | — | EP | claimed |
| WO-2007039736-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2007-04-12 | — | — | WO | claimed |
| EP-1937632-A1 | NOVEL COMPOUNDS | Astra Zeneca AB (SE) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007039736-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2007-04-12 | — | — | WO | disclosed |