Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 7/20 | 0.41 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4639087 | 0.88 | EPAS1 (0.44) | PTGDR2EPAS1SMN1; SMN2ALDH1A1MCL1 | |
| SCHEMBL4637496 | 0.86 | PTGDR2 (0.40) | PTGDR2EPAS1SMN1; SMN2ALDH1A1POLB | |
| SCHEMBL4637399 | 0.85 | EPAS1 (0.47) | PTGDR2EPAS1ALDH1A1HTR2ASLC6A4 | |
| SCHEMBL1651360 | 0.82 | EPAS1 (0.49) | PTGDR2EPAS1ALDH1A1MCL1 | |
| SCHEMBL4637476 | 0.82 | SCN9A (0.42) | PTGDR2SMN1; SMN2 | |
| SCHEMBL4637618 | 0.80 | KDM4E (0.40) | PTGDR2ALDH1A1 | |
| SCHEMBL4674539 | 0.76 | PTGDR2 (0.48) | PTGDR2ALDH1A1 | |
| SCHEMBL4637590 | 0.76 | PTGDR2 (0.46) | PTGDR2EPAS1BRD4 | |
| SCHEMBL4194515 | 0.75 | PTGDR2 (0.45) | PTGDR2EPAS1ALDH1A1POLBMCL1 | |
| SCHEMBL4637479 | 0.75 | PTGDR2 (0.41) | PTGDR2EPAS1SMN1; SMN2ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937632-A1 | NOVEL COMPOUNDS | Astra Zeneca AB (SE) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007039736-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2007-04-12 | — | — | WO | disclosed |