Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 5/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | MGLL | Q99685 | 1/20 | 0.30 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.30 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.30 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4639435 | 0.85 | USP2 (0.37) | USP2CYP3A4CYP2D6TSHRAKR1C3 | |
| SCHEMBL4637872 | 0.84 | USP2 (0.36) | USP2CYP3A4MEN1KMT2ACYP2D6 | |
| SCHEMBL4671709 | 0.82 | AKR1C3 (0.38) | USP2MEN1KMT2ACYP2D6TSHR | |
| SCHEMBL4638494 | 0.81 | USP2 (0.42) | USP2CYP3A4MEN1KMT2ACYP2D6 | |
| SCHEMBL4637963 | 0.81 | USP2 (0.45) | USP2CYP3A4MEN1KMT2ACYP2D6 | |
| SCHEMBL4637887 | 0.78 | USP2 (0.36) | USP2CYP3A4MEN1KMT2ACYP2D6 | |
| SCHEMBL4637960 | 0.78 | USP2 (0.41) | USP2CYP3A4MEN1KMT2ACYP2D6 | |
| SCHEMBL4638486 | 0.73 | GPBAR1 (0.34) | P2RX7KDM4E | |
| SCHEMBL4639407 | 0.73 | EPAS1 (0.37) | TSHRMAPTKDM4EALDH1A1 | |
| SCHEMBL5632871 | 0.70 | USP2 (0.36) | USP2CYP3A4MEN1KMT2ACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501808-B1 | TACHYKININ RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-07-02 | — | — | EP | disclosed |