Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 15/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TACR1 | P25103 | 1/20 | 0.31 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.31 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4638948 | 0.89 | ALDH1A1 (0.35) | GPBAR1KDM4ETACR1 | |
| SCHEMBL4639386 | 0.88 | ALDH1A1 (0.40) | KDM4ETACR1 | |
| SCHEMBL4639407 | 0.88 | EPAS1 (0.37) | GPBAR1KDM4EEPAS1 | |
| SCHEMBL4637953 | 0.87 | TACR1 (0.35) | GPBAR1KDM4ETACR1EPAS1 | |
| SCHEMBL4707570 | 0.86 | GPBAR1 (0.37) | GPBAR1KDM4EAVPR2AVPR1A | |
| SCHEMBL4707053 | 0.86 | GPBAR1 (0.34) | GPBAR1TACR1AVPR2AVPR1A | |
| SCHEMBL4705935 | 0.85 | AVPR2 (0.34) | GPBAR1TACR1AVPR2AVPR1A | |
| SCHEMBL4707379 | 0.85 | GPBAR1 (0.34) | GPBAR1KDM4ETACR1AVPR2AVPR1A | |
| SCHEMBL4639443 | 0.83 | P2RX7 (0.34) | GPBAR1AVPR2AVPR1AP2RX7 | |
| SCHEMBL4637892 | 0.83 | TACR1 (0.34) | KDM4ETACR1EPAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501808-B1 | TACHYKININ RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-07-02 | — | — | EP | disclosed |