Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 7/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CETP | P11597 | 1/20 | 0.33 |
| ▸ | TACR3 | P29371 | 4/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.32 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.32 |
| ▸ | TACR2 | P21452 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.31 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.31 |
| ▸ | MCTS1 | Q9ULC4 | 1/20 | 0.31 |
| ▸ | RAF1 | P04049 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4637953 | 0.88 | TACR1 (0.35) | TACR1ALDH1A1L3MBTL1TACR3KDM4E | |
| SCHEMBL4638634 | 0.88 | ALDH1A1 (0.39) | TACR1ALDH1A1TDP1L3MBTL1KDM4E | |
| SCHEMBL4708316 | 0.86 | TACR1 (0.33) | TACR1ALDH1A1TDP1L3MBTL1TACR3 | |
| SCHEMBL4706174 | 0.85 | ALDH1A1 (0.33) | TACR1ALDH1A1TDP1L3MBTL1TACR3 | |
| SCHEMBL4639386 | 0.85 | ALDH1A1 (0.40) | TACR1ALDH1A1KDM4EMAPTGAA | |
| SCHEMBL4705752 | 0.85 | ALDH1A1 (0.33) | TACR1ALDH1A1TDP1L3MBTL1TACR3 | |
| SCHEMBL4707466 | 0.84 | TACR1 (0.32) | TACR1ALDH1A1TDP1L3MBTL1TACR3 | |
| SCHEMBL4638948 | 0.84 | ALDH1A1 (0.35) | TACR1ALDH1A1KDM4EMAPT | |
| SCHEMBL4638486 | 0.83 | GPBAR1 (0.34) | TACR1KDM4EEPAS1 | |
| SCHEMBL4637845 | 0.82 | EPAS1 (0.41) | TACR1ALDH1A1TDP1L3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501808-B1 | TACHYKININ RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-07-02 | — | — | EP | disclosed |