Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 5/20 | 0.35 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.34 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.34 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.33 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.33 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.33 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.33 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.33 |
| ▸ | CETP | P11597 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | TACR3 | P29371 | 2/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.32 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | GRK5 | P34947 | 1/20 | 0.32 |
| ▸ | CDK8 | P49336 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4638510 | 0.87 | USP2 (0.40) | TACR1GPBAR1GRM2EPAS1GAA | |
| SCHEMBL4705059 | 0.86 | TACR1 (0.36) | TACR1GPBAR1GRM2EPAS1 | |
| SCHEMBL4708206 | 0.85 | TACR1 (0.35) | TACR1GPBAR1GRM2TACR3EPAS1 | |
| SCHEMBL4637953 | 0.83 | TACR1 (0.35) | TACR1GPBAR1GRM2TACR3EPAS1 | |
| SCHEMBL4638616 | 0.82 | CFTR (0.33) | TACR1RORCS1PR1S1PR5 | |
| SCHEMBL4707134 | 0.79 | EPAS1 (0.40) | TACR1GPBAR1GRM2EPAS1USP2 | |
| SCHEMBL4639431 | 0.79 | TACR1 (0.35) | TACR1GPBAR1PTGER4SIRT2SIRT1 | |
| SCHEMBL4758302 | 0.78 | TACR1 (0.37) | TACR1GPBAR1GRM2EPAS1LMNA | |
| SCHEMBL4707521 | 0.77 | TACR1 (0.37) | TACR1GPBAR1GRM2EPAS1USP2 | |
| SCHEMBL4638090 | 0.77 | EPAS1 (0.39) | TACR1GPBAR1EPAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501808-B1 | TACHYKININ RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-07-02 | — | — | EP | disclosed |