Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 3/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | TACR1 | P25103 | 6/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.37 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4705059 | 0.89 | TACR1 (0.36) | TACR1CYP3A4EPAS1GPBAR1TP53 | |
| SCHEMBL4708206 | 0.87 | TACR1 (0.35) | TACR1CYP3A4EPAS1GPBAR1TP53 | |
| SCHEMBL4637951 | 0.87 | TACR1 (0.35) | USP2CYP2D6TACR1EPAS1GPBAR1 | |
| SCHEMBL4637953 | 0.86 | TACR1 (0.35) | TACR1EPAS1GPBAR1TP53MAPT | |
| SCHEMBL4639351 | 0.86 | USP2 (0.39) | USP2CYP2D6TACR1CYP3A4CYP2C19 | |
| SCHEMBL4637947 | 0.86 | USP2 (0.36) | USP2CYP2D6TACR1CYP3A4CYP2C19 | |
| SCHEMBL14144554 | 0.85 | USP2 (0.38) | USP2CYP2D6TACR1CYP3A4CYP2C19 | |
| SCHEMBL4758302 | 0.84 | TACR1 (0.37) | USP2CYP2D6TACR1EPAS1GPBAR1 | |
| SCHEMBL4707521 | 0.83 | TACR1 (0.37) | USP2CYP2D6TACR1EPAS1GPBAR1 | |
| SCHEMBL4705619 | 0.83 | TACR1 (0.36) | TACR1EPAS1GPBAR1TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501808-B1 | TACHYKININ RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-07-02 | — | — | EP | disclosed |