Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 6/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.41 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | FLT4 | P35916 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL585199 | 0.90 | PTGS2 (0.49) | PTGS2MEN1KMT2ATP53AGTR1 | |
| SCHEMBL416071 | 0.77 | — | — | |
| SCHEMBL2393378 | 0.76 | GAA (0.42) | PTGDR2ALDH1A1 | |
| SCHEMBL806970 | 0.74 | GAA (0.47) | PTGS2KMT2APTGDR2SOS1PSEN1 | |
| SCHEMBL13601374 | 0.74 | MAPK1 (0.48) | MEN1KMT2APTGDR2ALDH1A1 | |
| SCHEMBL708295 | 0.73 | GAA (0.42) | MEN1KMT2APTGDR2ALDH1A1 | |
| SCHEMBL29678127 | 0.73 | GAA (0.42) | MEN1KMT2APTGDR2ALDH1A1 | |
| Silver SCHEMBL6115022 | 0.72 | SOS1 (0.49) | PTGS2MEN1KMT2ATP53AGTR1 | |
| SCHEMBL585689 | 0.72 | PTGS2 (0.65) | PTGS2MEN1KMT2ATP53AGTR1 | |
| SCHEMBL1251768 | 0.71 | PSIP1 (0.58) | PTGS2MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937632-A1 | NOVEL COMPOUNDS | Astra Zeneca AB (SE) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007039736-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2007-04-12 | — | — | WO | disclosed |