Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.35 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12591870 | 0.82 | ENPP1 (0.50) | NPC1TP53HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL20385746 | 0.80 | NPC1 (0.40) | IDO1NPC1RAB9ASMN1; SMN2NOTUM | |
| SCHEMBL4638064 | 0.77 | ENPP3 (0.55) | HSP90AA1HSP90AB1IDO1NPC1TP53 | |
| SCHEMBL10052155 | 0.75 | ENPP3 (0.45) | RAB9AKMT2AHSD11B1MAPTATM | |
| SCHEMBL24107475 | 0.74 | HSP90AA1 (0.50) | HSP90AA1HSP90AB1IDO1NPC1TP53 | |
| SCHEMBL30263376 | 0.74 | HSP90AA1 (0.50) | HSP90AA1HSP90AB1IDO1NPC1TP53 | |
| SCHEMBL6979612 | 0.70 | KMT2A (0.56) | NPC1TP53HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL24105994 | 0.70 | KDM4E (0.47) | NPC1TP53HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL23108239 | 0.70 | ENPP1 (0.36) | KMT2AENPP3ENPP1 | |
| SCHEMBL23093079 | 0.69 | HNF4A (0.45) | HPGDKMT2AL3MBTL1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501808-B1 | TACHYKININ RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-07-02 | — | — | EP | disclosed |
| CN-1649849-A | Tachykinin receptor antagonists | LILLY CO ELI (US) | 2005-08-03 | — | — | CN | disclosed |