Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 6/20 | 0.41 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4639520 | 0.89 | PARP1 (0.43) | POLBKDM4EHSD17B10MAPTRAB9A | |
| SCHEMBL4640557 | 0.88 | PDE4A (0.44) | LMNAMAPT | |
| SCHEMBL4639422 | 0.88 | SMN1; SMN2 (0.42) | SMN1; SMN2S1PR1S1PR3POLBKDM4E | |
| SCHEMBL4639857 | 0.88 | S1PR1 (0.40) | S1PR1S1PR3KDM4EHSD17B10LMNA | |
| SCHEMBL4640544 | 0.87 | PIK3CG (0.42) | SMN1; SMN2KDM4EHSD17B10LMNAUSP2 | |
| SCHEMBL4640052 | 0.87 | KDM4E (0.46) | S1PR1S1PR3KDM4EHSD17B10LMNA | |
| SCHEMBL5592710 | 0.86 | S1PR1 (0.41) | SMN1; SMN2S1PR1S1PR3POLBKDM4E | |
| SCHEMBL4639660 | 0.86 | KDM4E (0.41) | SMN1; SMN2S1PR1S1PR3POLBKDM4E | |
| SCHEMBL4639814 | 0.86 | KDM4E (0.41) | SMN1; SMN2S1PR1S1PR3POLBKDM4E | |
| SCHEMBL4641238 | 0.86 | LMNA (0.41) | SMN1; SMN2S1PR1S1PR3POLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1954684-A2 | OXAZOLE COMPOUND AND PHARMACEUTICAL COMPOSITION | Otsuka Pharmaceutical Co., Ltd. (JP) | 2008-08-13 | — | — | EP | disclosed |
| WO-2007058338-A2 | OXAZOLE COMPOUND AND PHARMACEUTICAL COMPOSITION | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-05-24 | — | — | WO | disclosed |