Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 2/20 | 0.40 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.40 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.35 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4640424 | 0.92 | KDM4E (0.39) | S1PR1S1PR3S1PR5PTGS2KDM4E | |
| SCHEMBL4639512 | 0.88 | LMNA (0.38) | S1PR1S1PR3S1PR5KDM4EHPGD | |
| SCHEMBL4641121 | 0.88 | KDM4E (0.42) | S1PR1S1PR3KDM4EHSD17B10LMNA | |
| SCHEMBL4639396 | 0.88 | SMN1; SMN2 (0.44) | S1PR1S1PR3KDM4EHPGDHSD17B10 | |
| SCHEMBL4640544 | 0.86 | PIK3CG (0.42) | PIK3CGKDM4EHPGDHSD17B10ABCB1 | |
| SCHEMBL5592984 | 0.86 | LMNA (0.36) | S1PR1S1PR3S1PR5KDM4EHPGD | |
| SCHEMBL5592764 | 0.85 | PARP1 (0.39) | S1PR1S1PR3S1PR5KDM4EHSD17B10 | |
| SCHEMBL4639475 | 0.85 | KDM4E (0.38) | S1PR1S1PR3S1PR5KDM4EHPGD | |
| SCHEMBL4639520 | 0.84 | PARP1 (0.43) | PTGS2PIK3CGKDM4EHPGDCYP2C19 | |
| SCHEMBL4640682 | 0.84 | PDE4A (0.43) | KDM4EHPGDHSD17B10PDE4BABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1954684-A2 | OXAZOLE COMPOUND AND PHARMACEUTICAL COMPOSITION | Otsuka Pharmaceutical Co., Ltd. (JP) | 2008-08-13 | — | — | EP | disclosed |
| WO-2007058338-A9 | OXAZOLE COMPOUND AND PHARMACEUTICAL COMPOSITION | OTSUKA PHARMA CO LTD (JP) | 2007-11-01 | — | — | WO | disclosed |
| WO-2007058338-A2 | OXAZOLE COMPOUND AND PHARMACEUTICAL COMPOSITION | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-05-24 | — | — | WO | disclosed |