Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 5/20 | 0.38 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5592963 | 0.93 | LMNA (0.35) | KDM4ERAB9AHSD17B10NPC1ALDH1A1 | |
| SCHEMBL4641168 | 0.93 | LMNA (0.35) | KDM4ERAB9AHSD17B10NPC1ALDH1A1 | |
| SCHEMBL4640052 | 0.92 | KDM4E (0.46) | KDM4ERAB9AHSD17B10NPC1ALDH1A1 | |
| SCHEMBL4639629 | 0.92 | PARP1 (0.44) | KDM4EHSD17B10ALDH1A1LMNAHPGD | |
| SCHEMBL4639865 | 0.86 | KDM4E (0.41) | KDM4EHSD17B10ALDH1A1LMNAHPGD | |
| SCHEMBL4641207 | 0.86 | KDM4E (0.43) | KDM4ERAB9AHSD17B10NPC1ALDH1A1 | |
| SCHEMBL5592764 | 0.85 | PARP1 (0.39) | KDM4EHSD17B10ALDH1A1LMNAS1PR1 | |
| SCHEMBL4639554 | 0.85 | PARP1 (0.41) | KDM4EHSD17B10ALDH1A1LMNAS1PR1 | |
| SCHEMBL4639520 | 0.85 | PARP1 (0.43) | KDM4ERAB9AHSD17B10ALDH1A1HPGD | |
| SCHEMBL5592918 | 0.84 | LMNA (0.39) | KDM4ERAB9AHSD17B10NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1954684-A2 | OXAZOLE COMPOUND AND PHARMACEUTICAL COMPOSITION | Otsuka Pharmaceutical Co., Ltd. (JP) | 2008-08-13 | — | — | EP | disclosed |
| WO-2007058338-A9 | OXAZOLE COMPOUND AND PHARMACEUTICAL COMPOSITION | OTSUKA PHARMA CO LTD (JP) | 2007-11-01 | — | — | WO | disclosed |
| WO-2007058338-A2 | OXAZOLE COMPOUND AND PHARMACEUTICAL COMPOSITION | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-05-24 | — | — | WO | disclosed |