Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | FNTA | P49354 | 2/20 | 0.34 |
| ▸ | FNTB | P49356 | 2/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL154342 | 0.98 | THRB (0.55) | THRBTSHRALDH1A1POLBAPEX1 | |
| Ammonia Solution, Strong SCHEMBL720362 | 0.96 | THRB (0.53) | THRBTSHRALDH1A1POLBAPEX1 | |
| SCHEMBL30876969 | 0.96 | THRB (0.53) | THRBTSHRALDH1A1POLBAPEX1 | |
| Trimethylammonium SCHEMBL6026219 | 0.93 | THRB (0.50) | THRBTSHRALDH1A1POLBAPEX1 | |
| SCHEMBL8362110 | 0.93 | THRB (0.59) | THRBTSHRALDH1A1POLBAPEX1 | |
| Dimethylamine SCHEMBL5034396 | 0.93 | THRB (0.50) | THRBTSHRALDH1A1POLBAPEX1 | |
| Trimethylammonium SCHEMBL27532167 | 0.91 | THRB (0.49) | THRBTSHRALDH1A1POLBAPEX1 | |
| Ammonia Solution, Strong SCHEMBL8943081 | 0.91 | THRB (0.58) | THRBTSHRALDH1A1POLBAPEX1 | |
| SCHEMBL5969177 | 0.87 | TSHR (0.55) | THRBTSHRALDH1A1POLBAPEX1 | |
| SCHEMBL5969201 | 0.87 | TSHR (0.59) | THRBTSHRALDH1A1POLBAPEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 82 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230137331-A1 | Activation and Expansion of T Cell Subsets Using Biocompatible Solid Substrates with Tunable Rigidity | UNIV PENNSYLVANIA (US) | 2023-05-04 | — | — | US | claimed |
| US-20150030619-A1 | Activation and Expansion of T Cell Subsets Using Biocompatible Solid Substrates with Tunable Rigidity | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2015-01-29 | — | — | US | claimed |
| WO-2013036585-A1 | ACTIVATION AND EXPANSION OF T CELL SUBSETS USING BIOCOMPATIBLE SOLID SUBSTRATES WITH TUNABLE RIGIDITY | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2013-03-14 | — | — | WO | claimed |
| EP-0580726-B2 | LOW DENSITY MICROSPHERES AND THEIR USE AS CONTRAST AGENTS FOR COMPUTED TOMOGRAPHY | IMARX PHARMACEUTICAL CORP (US) | 2008-08-20 | — | — | EP | claimed |
| US-6998107-B2 | Composition comprising low density microspheres | BRISTOL-MYERS SQUIBB PHARMA COMAPANY (US) | 2006-02-14 | — | — | US | claimed |
| US-20040223914-A1 | Composition comprising low density microspheres | BRISTOL-MYERS SQUIBB MEDICAL IMAGING INC. | 2004-11-11 | — | — | US | claimed |
| US-6773696-B2 | WHEREIN VOID COMPRISES VAPOR OF VOLATILE LIQUID (ALIPHATIC HYDROCARBONS, CHLOROFLUOROCARBONS, TETRAALKYL SILANES, AND PERFLUOROCARBONS); FOR COMPUTED TOMOGRAPHY IMAGING OF THE GASTROINTESTINAL REGION | BRISTOL-MYERS SQUIBB MEDICAL IMAGING, INC. | 2004-08-10 | — | — | US | claimed |
| US-20030053953-A1 | Contrast agent comprising low density microspheres | LANTHEUS MI REAL ESTATE, LLC | 2003-03-20 | — | — | US | claimed |
| US-6528039-B2 | Administering to a patient a contrast medium comprising a homogenous aqueous suspension of low density polymeric microsphere filled with a gas, scanning the patient using computed tomography imaging to obtain visible image of tissue | BRISTOL-MYERS SQUIBB MEDICAL IMAGING, INC. | 2003-03-04 | — | — | US | claimed |
| US-20010024639-A1 | LOW DENSITY MICROSPHERES AND THEIR USE AS CONTRAST AGENTS FOR COMPUTED TOMOGRAPHY AND IN OTHER APPLICATIONS | LANTHEUS HOLDINGS, INC. | 2001-09-27 | — | — | US | claimed |
| EP-0580726-B1 | LOW DENSITY MICROSPHERES AND THEIR USE AS CONTRAST AGENTS FOR COMPUTED TOMOGRAPHY | IMARX PHARMACEUTICAL CORP (US) | 1999-06-02 | — | — | EP | claimed |
| EP-0804932-A2 | Contrast media for diagnostic imaging comprising gas filled microspeures | ImaRx Pharmaceutical Corp. (US) | 1997-11-05 | — | — | EP | claimed |
| US-5547656-A | Low density microspheres and their use as contrast agents for computed tomography, and in other applications | IMARX PHARMACEUTICAL CORP. (US) | 1996-08-20 | — | — | US | claimed |
| US-5527521-A | AQUEOUS SUSPENSION OF BIOCOMPATIBLE POLYMER, A PERFLUOROCARBON GAS, AND A THICKENING OR SUSPENDING AGENT | IMARX PHARMACEUTICAL CORP. (US) | 1996-06-18 | — | — | US | claimed |
| US-5456900-A | Low density microspheres and their use as contrast agents for computed tomography | CITIZENS BANK, N.A. | 1995-10-10 | — | — | US | claimed |
| EP-0580726-A4 | LOW DENSITY MICROSPHERES AND THEIR USE AS CONTRAST AGENTS FOR COMPUTED TOMOGRAPHY. | UNGER EVAN C (US) | 1995-03-29 | — | — | EP | claimed |
| EP-0580726-A1 | LOW DENSITY MICROSPHERES AND THEIR USE AS CONTRAST AGENTS FOR COMPUTED TOMOGRAPHY | IMARX PHARMACEUTICAL CORP. (US) | 1994-02-02 | — | — | EP | claimed |
| US-5281408-A | Low density microspheres and their use as contrast agents for computed tomography | CITIZENS BANK, N.A. | 1994-01-25 | — | — | US | claimed |
| US-5205290-A | LOW DENSITY MICROSPHERES AND THEIR USE AS CONTRAST AGENTS FOR COMPUTED TOMOGRAPHY | CITIZENS BANK, N.A. | 1993-04-27 | — | — | US | claimed |
| WO-1992017514-A1 | LOW DENSITY MICROSPHERES AND THEIR USE AS CONTRAST AGENTS FOR COMPUTED TOMOGRAPHY | UNGER EVAN C (US) | 1992-10-15 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040223914-A1 | Composition comprising low density microspheres | MSR1, CD68, SGMS1 | THRB 2173/4885TSHR 1262/4885ALDH1A1 2865/4885 |
| US-20010024639-A1 | LOW DENSITY MICROSPHERES AND THEIR USE AS CONTRAST AGENTS FOR COMPUTED TOMOGRAPHY AND IN OTHER APPLICATIONS | FABP2, FABP6, MLNR | THRB 2387/4885TSHR 716/4885ALDH1A1 4309/4885 |
| US-20030053953-A1 | Contrast agent comprising low density microspheres | MSR1, CD68, MTDH | THRB 2050/4885TSHR 561/4885ALDH1A1 3109/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.