Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 2/20 | 0.44 |
| ▸ | DPP4 | P27487 | 2/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.41 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.41 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.41 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL79982 | 0.93 | PNMT (0.50) | PNMTDPP4GABRA1GABRB2CSNK2A2 | |
| Hydrochloric Acid SCHEMBL2782160 | 0.90 | PNMT (0.48) | PNMTDPP4GABRA1GABRB2CSNK2A2 | |
| Bromide SCHEMBL28831558 | 0.90 | PNMT (0.48) | PNMTDPP4GABRA1GABRB2CSNK2A2 | |
| SCHEMBL4639617 | 0.88 | PNMT (0.46) | PNMTDPP4GABRA1GABRB2CSNK2A2 | |
| Ethylamine SCHEMBL28337086 | 0.82 | GABRA1 (0.50) | PNMTGABRA1GABRB2CSNK2A2CSNK2B | |
| Methylamine SCHEMBL28339099 | 0.79 | PNMT (0.57) | PNMTDPP4SLC6A2SLC6A4SLC6A3 | |
| Methylamine SCHEMBL27540110 | 0.79 | GABRA1 (0.52) | GABRA1GABRB2CSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL25425763 | 0.79 | GABRA1 (0.58) | GABRA1GABRB2MGLLMAPTALDH1A1 | |
| SCHEMBL29390847 | 0.79 | GABRA1 (0.58) | GABRA1GABRB2MGLLMAPTALDH1A1 | |
| SCHEMBL36294 | 0.79 | GABRA1 (0.58) | GABRA1GABRB2MGLLMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951689-A1 | P2X7 RECEPTOR ANTAGONISTS AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007056046-A1 | P2X7 RECEPTOR ANTAGONISTS AND METHODS OF USE | ABBOTT LABORATORIES (US) | 2007-05-18 | — | — | WO | disclosed |