Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 10/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4639823 | 0.77 | BACE1 (0.52) | BACE1MEN1KMT2AKDM4E | |
| SCHEMBL4639688 | 0.77 | BACE1 (0.52) | BACE1MEN1KMT2AKDM4E | |
| SCHEMBL4133983 | 0.73 | BACE1 (0.55) | BACE1KDM4EHSD11B1 | |
| SCHEMBL4146188 | 0.68 | BACE1 (0.67) | BACE1KDM4E | |
| SCHEMBL4639694 | 0.67 | BACE1 (0.57) | BACE1MEN1KMT2ANPC1HSP90AA1 | |
| SCHEMBL4640096 | 0.67 | BACE1 (0.57) | BACE1MEN1KMT2ANPC1HSP90AA1 | |
| SCHEMBL4639697 | 0.67 | BACE1 (0.57) | BACE1MEN1KMT2ANPC1HSP90AA1 | |
| SCHEMBL1751871 | 0.66 | HSD11B1 (0.62) | MEN1KMT2ANPC1HSP90AA1RAB9A | |
| SCHEMBL297691 | 0.66 | HSD11B1 (0.62) | MEN1KMT2ANPC1HSP90AA1RAB9A | |
| SCHEMBL31613215 | 0.66 | HSD11B1 (0.62) | MEN1KMT2ANPC1HSP90AA1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951682-A1 | NOVEL 2-AMINOPYRIMIDINONE OR 2-AMINOPYRIDINONE DERIVATIVES AND THEIR USE | Astra Zeneca AB (SE) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007058582-A1 | NOVEL 2-AMINOPYRIMIDINONE OR 2-AMINOPYRIDINONE DERIVATIVES AND THEIR USE | ASTRAZENECA AB (SE) | 2007-05-24 | — | — | WO | disclosed |