SCHEMBL1751871

SCHEMBL1751871

Brc1ccccc1C=Cc1ccccc1Br

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD11B1 P28845 3/20 0.62
KMT2A Q03164 3/20 0.47
MEN1 O00255 2/20 0.47
NPC1 O15118 1/20 0.47
HSP90AA1 P07900 1/20 0.47
RAB9A P51151 1/20 0.47
BCHE P06276 1/20 0.47
PDGFRB P09619 1/20 0.46
FGFR1 P11362 1/20 0.46
FGFR3 P22607 1/20 0.46
NFE2L2 Q16236 1/20 0.46
LY96 Q9Y6Y9 1/20 0.46
IKBKB O14920 1/20 0.43
DYRK2 Q92630 1/20 0.43
CHRNA7 P36544 1/20 0.41
ALDH1A1 P00352 2/20 0.41
EGFR P00533 1/20 0.40
ATM Q13315 1/20 0.40
METAP2 P50579 1/20 0.39
RELA Q04206 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL297691 1.00 HSD11B1 (0.62) HSD11B1KMT2AMEN1NPC1HSP90AA1
SCHEMBL8900317 1.00 HSD11B1 (0.62) HSD11B1KMT2AMEN1NPC1HSP90AA1
SCHEMBL31613215 1.00 HSD11B1 (0.62) HSD11B1KMT2AMEN1NPC1HSP90AA1
SCHEMBL3328957 0.89 HSD11B1 (0.54) HSD11B1KMT2AMEN1NPC1HSP90AA1
SCHEMBL3328961 0.89 HSD11B1 (0.54) HSD11B1KMT2AMEN1NPC1HSP90AA1
SCHEMBL14752283 0.89 HSD11B1 (0.54) HSD11B1KMT2AMEN1NPC1HSP90AA1
SCHEMBL38650618 0.88 HSD11B1 (0.58) HSD11B1KMT2AMEN1NPC1HSP90AA1
SCHEMBL1812179 0.88 HSD11B1 (0.58) HSD11B1KMT2AMEN1NPC1HSP90AA1
SCHEMBL30364986 0.87 NFE2L2 (0.56) HSD11B1KMT2AMEN1NPC1NFE2L2
SCHEMBL14703725 0.87 NFE2L2 (0.56) HSD11B1KMT2AMEN1NPC1NFE2L2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 77 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4610657-A1 DIAGNOSIS OF IMMUNE-MEDIATED INFLAMMATORY DISEASES USING MMP12 AS INDICATOR, AND MEDICINE FOR TREATING IMMUNE-MEDIATED INFLAMMATORY DISEASES VIA MMP12 INHIBITION Keio University (JP) 2025-09-03 EP disclosed
US-12096682-B2 Organic electroluminescence device and monoamine compound for organic electroluminescence device SAMSUNG DISPLAY CO., LTD. (KR) 2024-09-17 US disclosed
WO-2024090571-A1 DIAGNOSIS OF IMMUNE-MEDIATED INFLAMMATORY DISEASES USING MMP12 AS INDICATOR, AND MEDICINE FOR TREATING IMMUNE-MEDIATED INFLAMMATORY DISEASES VIA MMP12 INHIBITION 慶應義塾 2024-05-02 WO disclosed
EP-3508472-B1 ORGANIC ELECTROLUMINESCENCE DEVICE AND MONOAMINE COMPOUND FOR ORGANIC ELECTROLUMINESCENCE DEVICE SAMSUNG DISPLAY CO LTD (KR) 2021-10-20 EP disclosed
EP-3508472-A1 ORGANIC ELECTROLUMINESCENCE DEVICE AND MONOAMINE COMPOUND FOR ORGANIC ELECTROLUMINESCENCE DEVICE Samsung Display Co., Ltd. (KR) 2019-07-10 EP disclosed
US-20190207117-A1 ORGANIC ELECTROLUMINESCENCE DEVICE AND MONOAMINE COMPOUND FOR ORGANIC ELECTROLUMINESCENCE DEVICE SAMSUNG DISPLAY CO., LTD. (KR) 2019-07-04 US disclosed
US-7968735-B2 Light-emitting biomarker QUIDD (FR) 2011-06-28 US disclosed
US-20090041669-A1 Light-Emitting Biomarker QUIDD (FR) 2009-02-12 US disclosed
EP-1883635-A2 LIGHT-EMITTING BIOMARKER Quidd (FR) 2008-02-06 EP disclosed
WO-2006129036-A2 LIGHT-EMITTING BIOMARKER QUIDD (FR) 2006-12-07 WO disclosed
US-4978614-A RELEASING LIGHT ENERGY; LUMINESCENCE TROPIX, INC. (US) 1990-12-18 US disclosed
US-4956477-A Synthesis of 1,2-dioxetanes TROPIX, INC. (US) 1990-09-11 US disclosed
US-4952707-A DECOMPOSITION TO LIGHT EMITTING FLUOROPHORE; ANALYSIS TROPIX, INC. (US) 1990-08-28 US disclosed
US-4931223-A MIXTURE RELEASING LIGHT OF DIFFERENT WAVELENGTHS BY ENZYME DECOMPOSITION TROPIX, INC. (US) 1990-06-05 US disclosed
EP-0368946-A1 1,2-DIOXETANES. QUEST SYSTEMS INC (US) 1990-05-23 EP disclosed
EP-0368946-A4 1,2-DIOXETANES. QUEST SYSTEMS INC (US) 1990-05-14 EP disclosed
EP-0275260-A4 METHOD OF DETECTING A SUBSTANCE USING ENZYMATICALLY-INDUCED DECOMPOSITION OF DIOXETANES. QUEST SYSTEMS INC (US) 1990-01-08 EP disclosed
WO-1989006226-A1 SYNTHESIS OF 1,2-DIOXETANES AND INTERMEDIATES THEREFOR QUEST SYSTEMS, INC. (US) 1989-07-13 WO disclosed
EP-0275260-A1 METHOD OF DETECTING A SUBSTANCE USING ENZYMATICALLY-INDUCED DECOMPOSITION OF DIOXETANES. QUEST SYSTEMS INC (US) 1988-07-27 EP disclosed
WO-1988000695-A1 METHOD OF DETECTING A SUBSTANCE USING ENZYMATICALLY-INDUCED DECOMPOSITION OF DIOXETANES QUEST SYSTEMS, INC. (US) 1988-01-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12096682-B2 Organic electroluminescence device and monoamine compound for organic electroluminescence device MAOA, MAOB, COMT HSD11B1 927/4885KMT2A 731/4885MEN1 1574/4885
US-20190207117-A1 ORGANIC ELECTROLUMINESCENCE DEVICE AND MONOAMINE COMPOUND FOR ORGANIC ELECTROLUMINESCENCE DEVICE MAOA, MAOB, COMT HSD11B1 927/4885KMT2A 731/4885MEN1 1574/4885
US-20090041669-A1 Light-Emitting Biomarker ALDH1A2, CYP19A1, GUSB HSD11B1 100/4885KMT2A 3231/4885MEN1 2465/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.