Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB3 | P13945 | 3/20 | 0.36 |
| ▸ | F2 | P00734 | 4/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | FABP4 | P15090 | 1/20 | 0.33 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.32 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.32 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | KIT | P10721 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4918863 | 0.91 | KEAP1 (0.38) | ADRB3F2OPRM1OPRD1HPGD | |
| SCHEMBL4830639 | 0.88 | ADRB3 (0.36) | ADRB3F2OPRM1OPRD1HPGD | |
| SCHEMBL4645777 | 0.87 | ADRB3 (0.40) | ADRB3F2OPRM1OPRD1HPGD | |
| SCHEMBL4639786 | 0.87 | ADRB3 (0.42) | ADRB3F2OPRM1OPRD1HPGD | |
| SCHEMBL4777051 | 0.86 | ADRB3 (0.37) | ADRB3F2OPRM1OPRD1HPGD | |
| SCHEMBL4840597 | 0.86 | ADRB3 (0.37) | ADRB3F2OPRM1OPRD1HPGD | |
| SCHEMBL4605628 | 0.85 | ADRB3 (0.42) | ADRB3F2OPRM1OPRD1HPGD | |
| SCHEMBL4778948 | 0.85 | ADRB3 (0.37) | ADRB3F2OPRM1OPRD1HPGD | |
| SCHEMBL4605863 | 0.85 | NR1I2 (0.40) | ADRB3OPRM1OPRD1HPGDNR1I2 | |
| SCHEMBL4918960 | 0.84 | ADRB3 (0.38) | ADRB3F2OPRM1OPRD1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1943229-A1 | BENZIMIDAZOLE DERIVATIVES FOR USE AS BETA-3 RECEPTOR AGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-07-16 | — | — | EP | disclosed |
| WO-2007048842-A1 | BENZIMIDAZOLE DERIVATIVES FOR USE AS BETA-3 RECEPTOR AGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-05-03 | — | — | WO | disclosed |