SCHEMBL4640554

SCHEMBL4640554

O=C(O)c1ccc(C(c2ccc(C(=O)O)cc2)C(c2ccc(C(=O)O)cc2)c2ccc(C(=O)O)cc2)cc1.[NaH].[NaH].[NaH].[NaH]

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.63
TP53 P04637 1/20 0.63
CA1 P00915 2/20 0.56
CA2 P00918 2/20 0.56
SRD5A2 P31213 5/20 0.55
CA12 O43570 1/20 0.52
CA3 P07451 1/20 0.52
TYR P14679 1/20 0.52
DRD1 P21728 1/20 0.52
CA4 P22748 1/20 0.52
CA6 P23280 1/20 0.52
CA5A P35218 1/20 0.52
CA7 P43166 1/20 0.52
CA9 Q16790 1/20 0.52
CA14 Q9ULX7 1/20 0.52
CA5B Q9Y2D0 1/20 0.52
ANPEP P15144 1/20 0.52
ALDH1A1 P00352 2/20 0.50
ALOX15 P16050 1/20 0.50
DAO P14920 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1596408 0.97 TSHR (0.67) TSHRTP53CA1CA2SRD5A2
SCHEMBL22472195 0.90 TSHR (0.59) TSHRTP53CA1CA2SRD5A2
SCHEMBL28002942 0.83 TSHR (0.55) TSHRTP53CA1CA2SRD5A2
Terephthalic Acid SCHEMBL1115993 0.83 TSHR (0.92) TSHRTP53CA1CA2SRD5A2
Terephthalic Acid SCHEMBL29199063 0.83 TSHR (0.92) TSHRTP53CA1CA2SRD5A2
Terephthalic Acid SCHEMBL104074 0.83 TSHR (0.92) TSHRTP53CA1CA2SRD5A2
SCHEMBL900831 0.81 TSHR (0.67) TSHRTP53CA1CA2SRD5A2
SCHEMBL9185162 0.80 RXRA (0.61) TSHRTP53CA1CA2SRD5A2
Terephthalic Acid SCHEMBL15641844 0.80 TSHR (0.86) TSHRTP53CA1CA2SRD5A2
Terephthalic Acid SCHEMBL7099415 0.80 TSHR (0.86) TSHRTP53CA1CA2SRD5A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1120391-B1 MOLECULAR COMPOUNDS CONTAINING NOVEL CARBOXYLIC ACID DERIVATIVES AS THE CONSTITUENT COMPOUND NIPPON SODA CO (JP) 2008-08-06 EP disclosed
US-6566548-B1 Alkylene- or phenylene- tetrabenzoic acids and derivatives NIPPON SODA CO., LTD. (JP) 2003-05-20 US disclosed
EP-1120391-A1 MOLECULAR COMPOUNDS CONTAINING NOVEL CARBOXYLIC ACID DERIVATIVES AS THE CONSTITUENT COMPOUND NIPPON SODA CO., LTD. (JP) 2001-08-01 EP disclosed