Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.92 |
| ▸ | TP53 | P04637 | 1/20 | 0.92 |
| ▸ | SRD5A2 | P31213 | 4/20 | 0.75 |
| ▸ | CA1 | P00915 | 3/20 | 0.71 |
| ▸ | CA2 | P00918 | 3/20 | 0.71 |
| ▸ | CA12 | O43570 | 1/20 | 0.71 |
| ▸ | CA3 | P07451 | 1/20 | 0.71 |
| ▸ | TYR | P14679 | 1/20 | 0.71 |
| ▸ | DRD1 | P21728 | 1/20 | 0.71 |
| ▸ | CA4 | P22748 | 1/20 | 0.71 |
| ▸ | CA6 | P23280 | 1/20 | 0.71 |
| ▸ | CA5A | P35218 | 1/20 | 0.71 |
| ▸ | CA7 | P43166 | 1/20 | 0.71 |
| ▸ | CA9 | Q16790 | 1/20 | 0.71 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.71 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.71 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.69 |
| ▸ | DAO | P14920 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Terephthalic Acid SCHEMBL1115993 | 1.00 | TSHR (0.92) | TSHRTP53SRD5A2CA1CA2 | |
| Terephthalic Acid SCHEMBL29199063 | 1.00 | TSHR (0.92) | TSHRTP53SRD5A2CA1CA2 | |
| Terephthalic Acid SCHEMBL11040866 | 0.96 | TSHR (0.86) | TSHRTP53SRD5A2CA1CA2 | |
| Terephthalic Acid SCHEMBL26133493 | 0.96 | TSHR (0.86) | TSHRTP53SRD5A2CA1CA2 | |
| Terephthalic Acid SCHEMBL7099415 | 0.96 | TSHR (0.86) | TSHRTP53SRD5A2CA1CA2 | |
| Terephthalic Acid SCHEMBL15641844 | 0.96 | TSHR (0.86) | TSHRTP53SRD5A2CA1CA2 | |
| Terephthalic Acid SCHEMBL15124722 | 0.96 | TSHR (0.86) | TSHRTP53SRD5A2CA1CA2 | |
| Terephthalic Acid SCHEMBL175823 | 0.96 | TSHR (1.00) | TSHRTP53SRD5A2CA1CA2 | |
| Terephthalic Acid SCHEMBL5053781 | 0.96 | TSHR (1.00) | TSHRTP53SRD5A2CA1CA2 | |
| Terephthalic Acid SCHEMBL2511919 | 0.96 | TSHR (1.00) | TSHRTP53SRD5A2CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1884 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12630710-B1 | 1,5-pentanediol-based polyester compositions with enhanced crystallization rates and methods of manufacture | THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA (US) | 2026-05-19 | — | — | US | claimed |
| CN-122011765-A | High-temperature-resistant reinforced polyphenylene sulfide composite material and preparation process thereof | 河南省第五地质勘查院有限公司 | 2026-05-12 | — | — | CN | claimed |
| CN-120737323-B | Flame-retardant anti-dripping polyester material and preparation method thereof | 河南源宏高分子新材料有限公司 | 2026-05-12 | — | — | CN | claimed |
| EP-4735413-A1 | CRYSTALLIZATION METHOD FOR PURIFIED TEREPHTHALIC ACID | DePoly SA (CH) | 2026-05-06 | — | — | EP | claimed |
| US-20260102359-A1 | COMBINATION TREATMENT OF DERMAL AND TRANSDERMAL FIBROTIC DISEASES, DISORDERS AND ASSOCIATED PAIN AND INFLAMMATION | ERESINA LLC (US) | 2026-04-16 | — | — | US | claimed |
| EP-4593859-A1 | COMBINATION TREATMENT OF DERMAL AND TRANSDERMAL FIBROTIC DISEASES, DISORDERS AND ASSOCIATED PAIN AND INFLAMMATION | Eresina, LLC (US) | 2025-08-06 | — | — | EP | claimed |
| US-20250214070-A1 | COMPOSITE CATALYST MATERIAL BASED ON RAPID MICROPLASTIC DEGRADATION AND PREPARATION METHOD AND APPLICATION THEREOF | UNIV ZHEJIANG SCIENCE & TECH (CN) | 2025-07-03 | — | — | US | claimed |
| EP-4571931-A2 | SECONDARY BATTERY, BATTERY MODULE COMPRISING SAME, BATTERY PACK, AND ELECTRICAL DEVICE | Contemporary Amperex Technology (Hong Kong) Limited (HK) | 2025-06-18 | — | — | EP | claimed |
| WO-2025120054-A1 | METHOD FOR PRODUCING A MOLDING | ALPLA WERKE ALWIN LEHNER GMBH & CO. KG (AT) | 2025-06-12 | — | — | WO | claimed |
| CN-120041872-A | Carbon dioxide reduction methane catalyst and air capture carbon dioxide-catalytic conversion device thereof | 中南大学 | 2025-05-27 | — | — | CN | claimed |
| US-6245844-B1 | MONO-SODIUM SALT OF A DICARBOXYLIC ACID | E. I. DU PONT DE NEMOURS AND COMPANY | 2001-06-12 | — | — | US | claimed |
| CN-1253942-A | Method for recovering benzoic acid from cobalt manganese residue discharged in the course of production of terephthalic acid | WEI SHIPING (CN) | 2000-05-24 | — | — | CN | claimed |
| WO-2000017265-A1 | NUCLEATING AGENT FOR POLYESTERS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2000-03-30 | — | — | WO | claimed |
| US-4923951-A | DIISOCYANTE, ALKALI OR ALKALINE EARTH METAL CATALYST | MITSUI TOATSU CHEMICALS, INCORPORATED (JP) | 1990-05-08 | — | — | US | claimed |
| EP-0328342-A2 | Process for producing aromatic polyamides | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1989-08-16 | — | — | EP | claimed |
| US-4834891-A | ALKALI METAL PHTHALATE, GLASS | DIRECTOR-GENERAL OF AGENCY OF INDUSTRIAL SCIENCE & TECHNOLOGY (JP) | 1989-05-30 | — | — | US | claimed |
| US-4737540-A | MOLDINGS HAVING MINIMIZED SINK MARKS | MITSUBISHI RAYON CO., LTD. (JP) | 1988-04-12 | — | — | US | claimed |
| US-4368283-A | HEAT RESISTANT MOLDING MATERIALS | MITSUBISHI RAYON CO., LTD. (JP) | 1983-01-11 | — | — | US | claimed |
| US-4093528-A | ELECTROLYSIS OF DISODIUM TEREPHTHALATE, CATION SELECTIVE MEMBRANE | SUNTECH, INC. (US) | 1978-06-06 | — | — | US | claimed |
| US-4039515-A | TEREPHTHALIC ACID | BASF AKTIENGESELLSCHAFT (DT) | 1977-08-02 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12630710-B1 | 1,5-pentanediol-based polyester compositions with enhanced crystallization rates and methods of manufacture | GRIN2D, SMCHD1, GRIN2C | TSHR 4102/4885TP53 2423/4885SRD5A2 472/4885 |
| US-20260102359-A1 | COMBINATION TREATMENT OF DERMAL AND TRANSDERMAL FIBROTIC DISEASES, DISORDERS AND ASSOCIATED PAIN AND INFLAMMATION | COL2A1, COLGALT1, PLOD3 | TSHR 4804/4885TP53 3329/4885SRD5A2 767/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.