Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGPAT2 | O15120 | 4/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.44 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | CASP3 | P42574 | 2/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.42 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.42 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | MCHR2 | Q969V1 | 1/20 | 0.41 |
| ▸ | CETP | P11597 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4643855 | 0.94 | AGPAT2 (0.45) | AGPAT2MCHR1KDRMAPTCASP3 | |
| SCHEMBL4641167 | 0.90 | AGPAT2 (0.46) | AGPAT2MAPTPOLB | |
| SCHEMBL5244630 | 0.87 | MAPT (0.53) | MCHR1KDRMAPTRXFP1KDM4E | |
| Hydrochloric Acid SCHEMBL5249374 | 0.86 | MAPT (0.52) | MCHR1KDRMAPTRXFP1KDM4E | |
| SCHEMBL4643568 | 0.85 | MCHR1 (0.47) | AGPAT2MCHR1KDRMAPTRXFP1 | |
| SCHEMBL4641580 | 0.84 | MAPT (0.48) | MCHR1MAPTRXFP1CETPSMN1; SMN2 | |
| SCHEMBL13054281 | 0.81 | MAPT (0.54) | MCHR1KDRMAPTRXFP1SMN1; SMN2 | |
| SCHEMBL4641410 | 0.81 | AGPAT2 (0.42) | AGPAT2MCHR1KDRMAPTCASP3 | |
| Hydrochloric Acid SCHEMBL5249492 | 0.80 | MAPT (0.53) | MCHR1KDRMAPTRXFP1SMN1; SMN2 | |
| SCHEMBL4643038 | 0.80 | MCHR1 (0.48) | MCHR1MAPTMCHR2SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828177-B1 | NOVEL MCH RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-08-13 | — | — | EP | claimed |