Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 4/20 | 0.47 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.46 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | UTRN | P46939 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4641580 | 0.92 | MAPT (0.48) | MCHR1ALDH1A1POLBNPC1RAB9A | |
| SCHEMBL4643855 | 0.86 | AGPAT2 (0.45) | MCHR1AGPAT2ALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL5247226 | 0.85 | MCHR1 (0.61) | MCHR1ALDH1A1POLBKDM4ESMN1; SMN2 | |
| SCHEMBL4641167 | 0.85 | AGPAT2 (0.46) | AGPAT2POLBMAPTTP53 | |
| SCHEMBL4641336 | 0.85 | AGPAT2 (0.46) | MCHR1AGPAT2ALDH1A1POLBNPC1 | |
| SCHEMBL3754747 | 0.81 | MCHR1 (0.63) | MCHR1MAPTHDAC6TP53MEN1 | |
| SCHEMBL4644600 | 0.81 | MAPT (0.45) | ALDH1A1POLBNPC1RAB9AKDM4E | |
| SCHEMBL4641261 | 0.79 | KDM4E (0.44) | MCHR1ALDH1A1POLBNPC1RAB9A | |
| SCHEMBL4641300 | 0.79 | AGPAT2 (0.42) | MCHR1AGPAT2PORCNALDH1A1POLB | |
| SCHEMBL4641319 | 0.78 | MAPT (0.42) | ALDH1A1POLBNPC1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828177-B1 | NOVEL MCH RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2008-08-13 | — | — | EP | claimed |