SCHEMBL4642159

SCHEMBL4642159

[CH2]C(C)C(=O)OC(=O)COc1cc(Cl)c(Cl)cc1Cl

nearest known ligand 0.67

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ TDP1 Q9NUW8 2/20 0.67
▸ L3MBTL1 Q9Y468 2/20 0.67
▸ TSHR P16473 2/20 0.67
▸ LMNA P02545 2/20 0.62
▸ SMN1; SMN2 Q16637 3/20 0.43
▸ NPC1 O15118 2/20 0.43
▸ RAB9A P51151 2/20 0.43
▸ KMT2A Q03164 2/20 0.43
▸ FKBP1A P62942 1/20 0.43
▸ MAPK1 P28482 1/20 0.42
▸ MAPT P10636 4/20 0.41
▸ ALDH1A1 P00352 2/20 0.41
▸ GAA P10253 1/20 0.41
▸ PKM P14618 1/20 0.41
▸ NPSR1 Q6W5P4 1/20 0.39
▸ MEN1 O00255 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4642345 0.85 L3MBTL1 (0.59) TDP1L3MBTL1TSHRLMNASMN1; SMN2
SCHEMBL28515884 0.84 LMNA (0.73) TDP1L3MBTL1TSHRLMNASMN1; SMN2
SCHEMBL4644001 0.81 LMNA (0.65) TDP1L3MBTL1TSHRLMNASMN1; SMN2
SCHEMBL4644003 0.81 LMNA (0.70) TDP1L3MBTL1TSHRLMNASMN1; SMN2
SCHEMBL29559528 0.80 TDP1 (1.00) TDP1L3MBTL1TSHRLMNASMN1; SMN2
SCHEMBL29827203 0.80 LMNA (0.68) TDP1L3MBTL1TSHRLMNASMN1; SMN2
SCHEMBL4645109 0.80 LMNA (0.63) TDP1L3MBTL1TSHRLMNASMN1; SMN2
SCHEMBL29559744 0.80 LMNA (0.68) TDP1L3MBTL1TSHRLMNASMN1; SMN2
SCHEMBL7185257 0.78 LMNA (0.60) TDP1L3MBTL1TSHRLMNASMN1; SMN2
SCHEMBL7186529 0.78 LMNA (0.60) TDP1L3MBTL1TSHRLMNASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1487928-B1 FILM-FORMING POLYMER AND ANTIFOULING PAINT JOTUN AS (NO) 2008-08-13 — — EP disclosed
EP-1487928-A1 FILM-FORMING POLYMER AND ANTIFOULING PAINT Jotun AS (NO) 2004-12-22 — — EP disclosed
WO-2003080747-A1 FILM-FORMING POLYMER AND ANTIFOULING PAINT JOTUN AS (NO) 2003-10-02 — — WO disclosed
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