Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | TOP2A | P11388 | 1/20 | 0.54 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.51 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.51 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.51 |
| ▸ | TUBB | P07437 | 1/20 | 0.51 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.51 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.51 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.51 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.51 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.51 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.51 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.51 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.51 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.51 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.51 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.51 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6691255 | 0.90 | TOP2A (0.45) | MAPTALDH1A1L3MBTL1TOP2AMTNR1A | |
| SCHEMBL4644205 | 0.85 | KMT2A (0.54) | MAPTALDH1A1L3MBTL1TOP2AMTNR1A | |
| SCHEMBL3105452 | 0.84 | MAPT (0.58) | MAPTALDH1A1L3MBTL1MTNR1AMTNR1B | |
| SCHEMBL3361882 | 0.84 | KMT2A (0.59) | MAPTALDH1A1L3MBTL1MTNR1AMTNR1B | |
| SCHEMBL30883175 | 0.82 | MAPT (0.57) | MAPTALDH1A1L3MBTL1MTNR1AMTNR1B | |
| SCHEMBL4643953 | 0.82 | MAPT (0.57) | MAPTALDH1A1L3MBTL1MTNR1AMTNR1B | |
| SCHEMBL362210 | 0.82 | MAPT (0.57) | MAPTALDH1A1L3MBTL1MTNR1AMTNR1B | |
| SCHEMBL4646037 | 0.82 | KMT2A (0.51) | MAPTALDH1A1L3MBTL1POLBSMN1; SMN2 | |
| SCHEMBL4646275 | 0.81 | KMT2A (0.50) | MAPTALDH1A1L3MBTL1TOP2APOLB | |
| SCHEMBL9615762 | 0.81 | MAPT (0.55) | MAPTALDH1A1L3MBTL1MTNR1AMTNR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220002232-A1 | PROCESS FOR THE PREPARATION OF 4,5-DIHYDROXY-2-(4-METHYLBENZYL)ISOPHTHALONITRILE | ORION CORPORATION (FI) | 2022-01-06 | — | — | US | claimed |
| EP-3877360-A1 | PROCESS FOR THE PREPARATION OF 4,5-DIHYDROXY-2-(4-METHYLBENZYL)ISOPHTHALONITRILE | Orion Corporation (FI) | 2021-09-15 | — | — | EP | claimed |
| CN-113166042-A | Method for preparing 4, 5-dihydroxy-2- (4-methylbenzyl) isophthalonitrile | 奥赖恩公司 | 2021-07-23 | — | — | CN | claimed |
| US-20220002232-A1 | PROCESS FOR THE PREPARATION OF 4,5-DIHYDROXY-2-(4-METHYLBENZYL)ISOPHTHALONITRILE | ORION CORPORATION (FI) | 2022-01-06 | — | — | US | disclosed |
| US-20220002232-A1 | PROCESS FOR THE PREPARATION OF 4,5-DIHYDROXY-2-(4-METHYLBENZYL)ISOPHTHALONITRILE | ORION CORPORATION (FI) | 2022-01-06 | — | — | US | disclosed |
| US-20220002232-A1 | PROCESS FOR THE PREPARATION OF 4,5-DIHYDROXY-2-(4-METHYLBENZYL)ISOPHTHALONITRILE | ORION CORPORATION (FI) | 2022-01-06 | — | — | US | disclosed |
| EP-3877360-A1 | PROCESS FOR THE PREPARATION OF 4,5-DIHYDROXY-2-(4-METHYLBENZYL)ISOPHTHALONITRILE | Orion Corporation (FI) | 2021-09-15 | — | — | EP | disclosed |
| EP-3877360-A1 | PROCESS FOR THE PREPARATION OF 4,5-DIHYDROXY-2-(4-METHYLBENZYL)ISOPHTHALONITRILE | Orion Corporation (FI) | 2021-09-15 | — | — | EP | disclosed |
| CN-113166042-A | Method for preparing 4, 5-dihydroxy-2- (4-methylbenzyl) isophthalonitrile | 奥赖恩公司 | 2021-07-23 | — | — | CN | disclosed |
| CN-113166042-A | Method for preparing 4, 5-dihydroxy-2- (4-methylbenzyl) isophthalonitrile | 奥赖恩公司 | 2021-07-23 | — | — | CN | disclosed |
| WO-2020094928-A1 | PROCESS FOR THE PREPARATION OF 4,5-DIHYDROXY-2-(4-METHYLBENZYL)ISOPHTHALONITRILE | ORION CORPORATION (FI) | 2020-05-14 | — | — | WO | disclosed |
| EP-1487928-B1 | FILM-FORMING POLYMER AND ANTIFOULING PAINT | JOTUN AS (NO) | 2008-08-13 | — | — | EP | disclosed |
| EP-1487928-A1 | FILM-FORMING POLYMER AND ANTIFOULING PAINT | Jotun AS (NO) | 2004-12-22 | — | — | EP | disclosed |
| WO-2003080747-A1 | FILM-FORMING POLYMER AND ANTIFOULING PAINT | JOTUN AS (NO) | 2003-10-02 | — | — | WO | disclosed |
| WO-1998008844-A1 | THIAZOLE DERIVATIVES USEFUL AS SELECTIVE INHIBITORS OF PDE-IV | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) | 1998-03-05 | — | — | WO | disclosed |
| US-4495352-A | HYPOTENSIVE AGENTS; VASODILATION; ADRENERGIC BLOCKING ACTION | MEAD JOHNSON & COMPANY (US) | 1985-01-22 | — | — | US | disclosed |
| US-4343940-A | 6- AND/OR 7-SUBSTITUTED WITH OXIRANYLMETHOXY | MEAD JOHNSON & COMPANY (US) | 1982-08-10 | — | — | US | disclosed |
| US-4314943-A | ANTIHYPERTENSIVE AGENTS; VASODILATORS | MEAD JOHNSON & COMPANY (US) | 1982-02-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220002232-A1 | PROCESS FOR THE PREPARATION OF 4,5-DIHYDROXY-2-(4-METHYLBENZYL)ISOPHTHALONITRILE | COMT, DDT, HPD | MAPT 3616/4885ALDH1A1 167/4885L3MBTL1 3314/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.