Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 6/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 6/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5426512 | 1.00 | OPRM1 (0.44) | OPRM1OPRL1CHRNB2CHRNA4LMNA | |
| SCHEMBL4645743 | 0.85 | CHRNB2 (0.51) | CHRNB2CHRNA4 | |
| SCHEMBL4642547 | 0.85 | CHRNB2 (0.51) | CHRNB2CHRNA4 | |
| SCHEMBL4642427 | 0.85 | CHRNB2 (0.51) | CHRNB2CHRNA4 | |
| SCHEMBL4644563 | 0.85 | CHRNB2 (0.51) | CHRNB2CHRNA4 | |
| Hydrochloric Acid SCHEMBL5109663 | 0.83 | CHRNB2 (0.52) | CHRNB2CHRNA4 | |
| Hydrochloric Acid SCHEMBL5108669 | 0.83 | CHRNB2 (0.52) | CHRNB2CHRNA4 | |
| SCHEMBL4644940 | 0.80 | OPRM1 (0.45) | OPRM1OPRL1CHRNB2CHRNA4LMNA | |
| SCHEMBL4642585 | 0.72 | CHRNB2 (0.51) | CHRNB2CHRNA4 | |
| SCHEMBL3152719 | 0.72 | CHRNB2 (0.51) | CHRNB2CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1748043-B1 | Polysubstituted 1,1-pyridinyloxycyclopropanamine derivatives, process for their préparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2008-08-20 | — | — | EP | disclosed |
| US-7348344-B2 | Polysubstituted 1,1-pyridyloxycyclopropanamine compounds | LES LABORATOIRES SERVIER (FR) | 2008-03-25 | — | — | US | disclosed |
| EP-1748043-A1 | Polysubstituted 1,1-pyridinyloxycyclopropanamine derivatives, process for their préparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2007-01-31 | — | — | EP | disclosed |