SCHEMBL4643567

SCHEMBL4643567

CC(=O)OC(=O)COCc1ccccc1

nearest known ligand 0.56

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.56
TSHR P16473 1/20 0.48
MAPK1 P28482 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
NPC1 O15118 2/20 0.46
MAPT P10636 1/20 0.46
GRM5 P41594 2/20 0.44
MAOB P27338 2/20 0.44
RAB9A P51151 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
SLC6A2 P23975 1/20 0.42
SLC6A3 Q01959 1/20 0.42
KMT2A Q03164 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
PAM P19021 1/20 0.41
BRD4 O60885 1/20 0.41
PTPN1 P18031 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11632800 0.89 TSHR (0.56) ALDH1A1TSHRMAPK1L3MBTL1NPC1
SCHEMBL9422962 0.86 TSHR (0.48) ALDH1A1TSHRMAPK1L3MBTL1NPC1
SCHEMBL11794032 0.83 ALDH1A1 (0.53) ALDH1A1TSHRMAPK1L3MBTL1NPC1
SCHEMBL4643563 0.82 TSHR (0.48) ALDH1A1TSHRMAPK1L3MBTL1NPC1
SCHEMBL1171919 0.81 TSHR (0.52) ALDH1A1TSHRMAPK1L3MBTL1NPC1
SCHEMBL4644595 0.81 MAPT (0.46) ALDH1A1TSHRMAPK1L3MBTL1NPC1
SCHEMBL712779 0.81 ALDH1A1 (0.59) ALDH1A1TSHRMAPK1L3MBTL1NPC1
SCHEMBL4644597 0.81 TSHR (0.47) ALDH1A1TSHRMAPK1L3MBTL1NPC1
SCHEMBL419807 0.79 ALDH1A1 (0.66) ALDH1A1TSHRMAPK1L3MBTL1GRM5
SCHEMBL4646684 0.79 MAPT (0.44) ALDH1A1TSHRMAPK1L3MBTL1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110092770-A A kind of preparation method of chromocor compound intermediate 北京盛诺基医药科技有限公司 2019-08-06 CN claimed
CN-110054605-A A kind of preparation method of icariine intermediate 北京盛诺基医药科技有限公司 2019-07-26 CN claimed
CN-110092770-A A kind of preparation method of chromocor compound intermediate 北京盛诺基医药科技有限公司 2019-08-06 CN disclosed
CN-110054605-A A kind of preparation method of icariine intermediate 北京盛诺基医药科技有限公司 2019-07-26 CN disclosed
EP-1487928-B1 FILM-FORMING POLYMER AND ANTIFOULING PAINT JOTUN AS (NO) 2008-08-13 EP disclosed
EP-1487928-A1 FILM-FORMING POLYMER AND ANTIFOULING PAINT Jotun AS (NO) 2004-12-22 EP disclosed
WO-2003080747-A1 FILM-FORMING POLYMER AND ANTIFOULING PAINT JOTUN AS (NO) 2003-10-02 WO disclosed
US-4078066-A HYPOTENSIVE AGENTS, SURFACTANTS, BACTERICIDES AND WATER SOFTENERS E. R. SQUIBB & SONS, INC. (US) 1978-03-07 US disclosed
US-4033971-A HYPOTENSIVES, SURFACTANTS, BACTERICIDES, WATER SOFTENERS E. R. SQUIBB & SONS, INC. (US) 1977-07-05 US disclosed